Microvascular Impairment in Patients With Cerebral Small Vessel Disease Assessed With Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Study

In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial tr...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Frontiers in aging neuroscience Ročník 14; s. 871612
Hlavní autori: Neumann, Katja, Günther, Matthias, Düzel, Emrah, Schreiber, Stefanie
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Research Foundation 19.05.2022
Frontiers Media S.A
Predmet:
Aging Neuroscience
Alzheimer's disease
arterial spin labeling
arterial transit time
Blood flow
Cerebral blood flow
cerebral small vessel disease
Cerebrovascular disease
clearance
Dementia
Magnetic resonance imaging
Metabolism
Microvasculature
Neuroimaging
Perfusion
Spin labeling
Substantia alba
Substantia grisea
Vascular diseases
Germany
T1-relaxation
magnetic resonance imaging
perfusion
cerebral blood flow
cerebral small vessel disease
clearance
arterial spin labeling
arterial transit time
ISSN:1663-4365, 1663-4365
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI). This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation time (T1eff) to research a novel approach of assessing perivascular clearance. CSVD severity was characterized using the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) and included a rating of white matter hyperintensities (WMHs), lacunes, enlarged perivascular spaces (EPVSs), and cerebral microbleeds (CMBs). Here, we found that CBF decreases and ATT increases with increasing CSVD severity in patients, most prominent for a white matter (WM) region-of-interest, whereas this relation was almost equally driven by WMHs, lacunes, EPVSs, and CMBs. Additionally, we observed a longer mean T1eff of gray matter and WM in patients with CSVD compared to elderly controls, providing an indication of impaired clearance in patients. Mainly T1eff of WM was associated with CSVD burden, whereas lobar lacunes and CMBs contributed primary to this relation compared to EPVSs of the centrum semiovale. Our results complement previous findings of CSVD-related hypoperfusion by the observation of retarded arterial blood arrival times in brain tissue and by an increased T1eff as potential indication of impaired clearance rates using ASL.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Edited by: Zhendong Liu, Shandong First Medical University, China
Reviewed by: Rahul Pratap Kotian, Gulf Medical University, United Arab Emirates; Xiaoniu Liang, Fudan University, China; Antonio Coca, University of Barcelona, Spain
This article was submitted to Neuroinflammation and Neuropathy, a section of the journal Frontiers in Aging Neuroscience
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.871612