Assessing the unified airway hypothesis in children via transcriptional profiling of the airway epithelium

Emerging evidence suggests that disease vulnerability is expressed throughout the airways, the so-called unified airway hypothesis, but the evidence to support this is predominantly indirect. We sought to establish the transcriptomic profiles of the upper and lower airways and determine their level...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 145; no. 6; pp. 1562 - 1573
Main Authors:	Kicic, Anthony, de Jong, Emma, Ling, Kak-Ming, Nichol, Kristy, Anderson, Denise, Wark, Peter A.B., Knight, Darryl A., Bosco, Anthony, Stick, Stephen M., Kicic-Starcevich, Elizabeth, Garratt, Luke W., Padros-Goosen, Marc, Tan, Ee-Lyn, Sutanto, Erika N., Looi, Kevin, Hillas, Jessica, Iosifidis, Thomas, Shaw, Nicole C., Montgomery, Samuel T., Martinovich, Kelly M., Lannigan, Francis J., Bergesio, Ricardo, Lee, Bernard, Vijaya-Sekeran, Shyan, Swan, Paul, Heaney, Mairead, Forsyth, Ian, Schoep, Tobias, Larcombe, Alexander, Hunter, Monica, McGee, Kate, Millington, Nyssa, Poh, Matthew W.-P., Laucirica, Daniel R., Schofield, Craig, McLean, Samantha, Landwehr, Katherine, Farrow, Nigel, Roscioli, Eugene, Parsons, David, Grainge, Christopher, Reid, Andrew T., Loo, Su-Ling, Veerati, Punnam C.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2020
Subjects:	Adolescent Airway epithelium biological processes Cell Adhesion Molecules - genetics Chemokine CCL26 - genetics Child Child, Preschool Cyclooxygenase 1 - genetics Epithelial Cells - metabolism Female gene expression Humans Hypersensitivity - genetics Male Receptors, Interleukin-1 Type I - genetics Respiratory Mucosa - metabolism Respiratory Sounds - genetics Respiratory System - metabolism Transcriptome - genetics transcriptomics unified airway hypothesis NTRK1 POSTN CDH Airway epithelium KRT CCL CST4 CST2 IL1RL1 CST1 transcriptomics CLCA1 unified airway hypothesis biological processes gene expression
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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