Syphilis in pregnancy: an ongoing public health threat

Syphilis is a treponemal infection that can be acquired sexually, hematogenously, or via vertical transmission from mother to infant. Despite evidence-based curative treatment options with penicillin, it remains a public health threat with increasing prevalence over recent years. Congenital syphilis...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:American journal of obstetrics and gynecology Ročník 227; číslo 6; s. 822 - 838
Hlavní autoři: Eppes, Catherine S., Stafford, Irene, Rac, Martha
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.12.2022
Témata:
congenital syphilis
Female
fetal syphilis
Humans
Infant
Infant, Newborn
Penicillin G Benzathine - therapeutic use
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - drug therapy
Pregnancy Complications, Infectious - epidemiology
Premature Birth - drug therapy
Public Health
reverse sequence
Syphilis - diagnosis
Syphilis - drug therapy
Syphilis - epidemiology
syphilis during pregnancy
syphilis testing
syphilis treatment
Syphilis, Congenital - epidemiology
Syphilis, Congenital - prevention & control
traditional algorithm
treponemal testing
United States - epidemiology
United States
syphilis during pregnancy
syphilis treatment
traditional algorithm
congenital syphilis
fetal syphilis
syphilis testing
treponemal testing
reverse sequence
ISSN:0002-9378, 1097-6868, 1097-6868
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Syphilis is a treponemal infection that can be acquired sexually, hematogenously, or via vertical transmission from mother to infant. Despite evidence-based curative treatment options with penicillin, it remains a public health threat with increasing prevalence over recent years. Congenital syphilis, a condition where a fetus acquires the infection during pregnancy, can lead to stillbirth, miscarriage, preterm birth, birth defects, and lifelong physical or neurologic changes. Congenital syphilis rates in the United States increased by 261% from 2013 to 2018 and continue to increase in 2021. The only recommended treatment for syphilis in pregnancy is benzathine penicillin G because evidence of decreased risk of congenital syphilis with other modalities is lacking. Testing for syphilis is complex and includes either the reverse-sequence algorithm or the traditional algorithm. Determination of the clinical stage of syphilis includes incorporation of the previous treatment sequence and physical examination. The goal of this review was to discuss the current evidence about optimal treatment and testing during pregnancy to optimize maternal health and prevent congenital syphilis.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0002-9378
1097-6868
1097-6868
DOI:10.1016/j.ajog.2022.07.041