Induction treatment with FOLFIRINOX or oxaliplatin-based doublet followed by long-course chemoradiotherapy and surgery in locally advanced rectal cancer. A systematic review and pooled analysis from phase II and III trials

•Induction chemotherapy with FOLFIRINOX followed by long-course CTRT versus CTRT alone improved survival outcomes.•The lack of head-to-head comparisons among triplet and doublet induction in LARC represents an unmet need.•We conducted a systematic review and IPSD pooled analysis including phase II-I...

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Bibliographic Details
Published in:	Cancer treatment reviews Vol. 130; p. 102829
Main Authors:	Moretto, Roberto, Vetere, Guglielmo, Carullo, Martina, Ciracì, Paolo, Masi, Gianluca, Cremolini, Chiara
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.11.2024
Subjects:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Chemoradiotherapy - methods Clinical Trials, Phase II as Topic Clinical Trials, Phase III as Topic Fluorouracil - administration & dosage Fluorouracil - therapeutic use FOLFIRINOX FOLFOX/CAPOX Humans Induction Chemotherapy - methods Induction treatment Irinotecan - administration & dosage Irinotecan - therapeutic use Leucovorin - administration & dosage Leucovorin - therapeutic use Locally advanced rectal cancer Neoadjuvant Therapy - methods Oxaliplatin - administration & dosage Oxaliplatin - therapeutic use Rectal Neoplasms - pathology Rectal Neoplasms - therapy Total neoadjuvant therapy FOLFIRINOX Locally advanced rectal cancer Induction treatment FOLFOX/CAPOX Total neoadjuvant therapy
ISSN:	0305-7372, 1532-1967, 1532-1967
Online Access:	Get full text
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