Nuances of PFKFB3 Signaling in Breast Cancer

•Cellular metabolism, survival, and proliferation are linked with PFKFB3 activity.•Hormonal status drives PFKFB3 activity in breast cancer.•PFKFB3 links external stimuli to cellular responses via kinase cascades.•Anti-PFKFB3 therapy has a suppressive effect over cell functions due to various mechani...

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Bibliographic Details
Published in:	Clinical breast cancer Vol. 22; no. 4; pp. e604 - e614
Main Authors:	Galindo, Claudia Martins, Oliveira Ganzella, Fernando Augusto de, Klassen, Giseli, Souza Ramos, Edneia Amancio de, Acco, Alexandra
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2022
Subjects:	Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Female Glycolysis Hormone receptor Humans Kinase cascades Metabolic therapy Phosphofructokinase-2 - genetics Phosphofructokinase-2 - metabolism Phosphorylation Signal Transduction Hormone receptor PRB PR HK iPFK-2 OXPHOS uPFK-2 BRCA1 E2 NF-κB SQSTM1/p62 BLBC PI3K mTOR PFKFB p90RSK PIM2 SHR EC F6P ERα PKC MAPK ER Kinase cascades G6Pase AMPK ERE mTORC1 ERK PFKFB3 SRF MSK1 IKKβ EGFR HIF-1 PPP Metabolic therapy SCF–β-TrCP E2F1 HUVEC miRNA BRCT PFK158 TIGAR P4 APC/C-Cdh1 VEGF Vmax Breast cancer AKT PFK-1 PFK15 3PO PFK-2 STAT JAK GPER Glycolysis EGR-1 HRE PK GLUT4 HER2 ATP
ISSN:	1526-8209, 1938-0666, 1938-0666
Online Access:	Get full text
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