Effect of Dietary Supplementation with Eufortyn® Colesterolo Plus on Serum Lipids, Endothelial Reactivity, Indexes of Non-Alcoholic Fatty Liver Disease and Systemic Inflammation in Healthy Subjects with Polygenic Hypercholesterolemia: The ANEMONE Study

We aimed to evaluate if dietary supplementation with a nutraceutical compound (Eufortyn® Colesterolo Plus) containing standardized bergamot polyphenolic fraction phytosome (Vazguard®), artichoke extract (Pycrinil®), artichoke dry extract. (Cynara scolymus L.), Q10 phytosome(Ubiqosome®) and zinc, cou...

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Vydané v:Nutrients Ročník 14; číslo 10; s. 2099
Hlavní autori: Fogacci, Federica, Rizzoli, Elisabetta, Giovannini, Marina, Bove, Marilisa, D’Addato, Sergio, Borghi, Claudio, Cicero, Arrigo F. G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 18.05.2022
MDPI
Predmet:
Alcoholism
Anemone
Apolipoproteins
Biological Products - therapeutic use
Blood pressure
Body mass index
C-Reactive Protein
Cholesterol
Cholesterol, LDL
Cynara scolymus
Diabetes
Diet
Dietary Supplements
Epidemiology
Fatty liver
Federal regulation
Flavonoids
Gene expression
Good Manufacturing Practice
Healthy Volunteers
High density lipoprotein
Humans
Hypercholesterolemia - drug therapy
Hypertension
Inflammation
Inflammation - drug therapy
ISO standards
Laboratories
Lipid Metabolism, Inborn Errors
Lipids
Liver diseases
Non-alcoholic Fatty Liver Disease - drug therapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Womens health
Zinc - therapeutic use
Italy
artichoke
cholesterol
bergamot
dietary supplement
nutraceutical compound
ISSN:2072-6643, 2072-6643
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Shrnutí:We aimed to evaluate if dietary supplementation with a nutraceutical compound (Eufortyn® Colesterolo Plus) containing standardized bergamot polyphenolic fraction phytosome (Vazguard®), artichoke extract (Pycrinil®), artichoke dry extract. (Cynara scolymus L.), Q10 phytosome(Ubiqosome®) and zinc, could positively affect serum lipids concentration, systemic inflammation and indexes of non-alcoholic fatty liver disease (NAFLD) in 60 healthy subjects with polygenic hypercholesterolemia. Participants were adhering to a low-fat, low-sodium Mediterranean diet for a month before being randomly allocated to 8-week treatment with 1 pill each day of either Eufortyn® Colesterolo Plus or placebo. Dietary supplementation with Eufortyn® Colesterolo Plus was associated with significant improvement in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), high-sensitivity C-reactive protein (hs-CRP) and endothelial reactivity (ER) in comparison with baseline, and with significant reductions in waist circumference, TC, LDL-C, LDL-C/HDL-C, lipid accumulation product and fatty liver index compared to placebo. The study shows that dietary supplementation with standardized bergamot polyphenolic fraction phytosome, artichoke extracts, Q10 phytosome and zinc safely exerts significant improvements in serum lipids, systemic inflammation, indexes of NAFLD and endothelial reactivity in healthy subjects with moderate hypercholesterolemia.
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ISSN:2072-6643
2072-6643
DOI:10.3390/nu14102099