The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy

During human uterine spiral artery (SpA) remodeling, vascular smooth muscle cells (VSMCs) are lost and replaced by fibrinoid, incorporating extravillous trophoblast (EVT) cells. The aim of the current study was to determine the relative contributions of apoptosis and migration to VSMC loss during Sp...

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Bibliographic Details
Published in:	The FASEB journal Vol. 26; no. 7; p. 2975
Main Authors:	Bulmer, Judith N, Innes, Barbara A, Levey, Joanne, Robson, Stephen C, Lash, Gendie E
Format:	Journal Article
Language:	English
Published:	United States 01.07.2012
Subjects:	Angiopoietin-2 - pharmacology Apoptosis - physiology Calmodulin-Binding Proteins - metabolism Caspase 3 - metabolism Cell Line Cell Movement - drug effects Cell Movement - physiology Female Humans Immunohistochemistry Lamins - metabolism Matrix Metalloproteinases - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - physiology Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - physiology Pregnancy Transforming Growth Factor beta1 - pharmacology Trophoblasts - cytology Trophoblasts - physiology Urokinase-Type Plasminogen Activator - metabolism Uterine Artery - cytology Uterine Artery - physiology Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor C - pharmacology
ISSN:	1530-6860, 1530-6860
Online Access:	Get more information
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