PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications

Biomaterial-based scaffolds are important cues in tissue engineering (TE) applications. Recent advances in TE have led to the development of suitable scaffold architecture for various tissue defects. In this narrative review on polycaprolactone (PCL), we have discussed in detail about the synthesis...

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Bibliographic Details
Published in:Molecular biotechnology Vol. 60; no. 7; pp. 506 - 532
Main Authors: Siddiqui, Nadeem, Asawa, Simran, Birru, Bhaskar, Baadhe, Ramaraju, Rao, Sreenivasa
Format: Journal Article
Language:English
Published: New York Springer US 01.07.2018
Springer Nature B.V
Subjects:
Biochemistry
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Biological Techniques
Biomaterials
Biotechnology
Cell Biology
ceramics
Ceramics - chemistry
Chemistry
Chemistry and Materials Science
Human Genetics
Polycaprolactone
Polyesters - chemical synthesis
Polyesters - chemistry
Polymers
Polymers - chemistry
Protein Science
Review
Scaffolds
Stem cells
Tissue engineering
Tissue Engineering - instrumentation
tissue repair
Tissue Scaffolds - chemistry
PCL
Composite
Stem cells and tissue engineering
Scaffolds
ISSN:1073-6085, 1559-0305, 1559-0305
Online Access:Get full text
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Summary:Biomaterial-based scaffolds are important cues in tissue engineering (TE) applications. Recent advances in TE have led to the development of suitable scaffold architecture for various tissue defects. In this narrative review on polycaprolactone (PCL), we have discussed in detail about the synthesis of PCL, various properties and most recent advances of using PCL and PCL blended with either natural or synthetic polymers and ceramic materials for TE applications. Further, various forms of PCL scaffolds such as porous, films and fibrous have been discussed along with the stem cells and their sources employed in various tissue repair strategies. Overall, the present review affords an insight into the properties and applications of PCL in various tissue engineering applications.
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ISSN:1073-6085
1559-0305
1559-0305
DOI:10.1007/s12033-018-0084-5