Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies

Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocations leading to NUP98 gene fusions i...

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Vydané v:	Blood Ročník 136; číslo 20; s. 2275
Hlavní autori:	Michmerhuizen, Nicole L, Klco, Jeffery M, Mullighan, Charles G
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 12.11.2020
Predmet:	Animals Hematologic Neoplasms - genetics Humans Nuclear Pore Complex Proteins - genetics Oncogene Proteins, Fusion - genetics
ISSN:	1528-0020, 1528-0020
On-line prístup:	Zistit podrobnosti o prístupe
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