TYMS presents a novel biomarker for diagnosis and prognosis in patients with pancreatic cancer
Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specifi...
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| Published in: | Medicine (Baltimore) Vol. 98; no. 51; p. e18487 |
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| Abstract | Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specific role of TYMS in pancreatic cancer has not been identified. This study was designed to clarify the diagnostic and prognostic significance of TYMS in pancreatic cancer.The Cancer Genome Atlas (TCGA) database was used to compare TYMS expression in pancreatic cancer, and ROC curve analysis was used to investigate its diagnostic value. The correlation between clinical characteristics and TYMS expression was analyzed, and the prognostic value of TYMS expression in the patients with pancreatic cancer was assessed by Kaplan-Meier curves and Cox analysis.TYMS was upregulated in pancreatic cancer and associated with poor overall survival (OS) and recurrence-free survival (RFS). Univariate and multivariate survival analysis demonstrated that TYMS is an independent risk factor for OS and RFS in patients with pancreatic cancer.The upregulation of TYMS in pancreatic cancer leads to unfavorable OS and RFS in patients, and represents a diagnostic and prognostic biomarker for patients with pancreatic cancer. |
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| AbstractList | Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specific role of TYMS in pancreatic cancer has not been identified. This study was designed to clarify the diagnostic and prognostic significance of TYMS in pancreatic cancer.The Cancer Genome Atlas (TCGA) database was used to compare TYMS expression in pancreatic cancer, and ROC curve analysis was used to investigate its diagnostic value. The correlation between clinical characteristics and TYMS expression was analyzed, and the prognostic value of TYMS expression in the patients with pancreatic cancer was assessed by Kaplan-Meier curves and Cox analysis.TYMS was upregulated in pancreatic cancer and associated with poor overall survival (OS) and recurrence-free survival (RFS). Univariate and multivariate survival analysis demonstrated that TYMS is an independent risk factor for OS and RFS in patients with pancreatic cancer.The upregulation of TYMS in pancreatic cancer leads to unfavorable OS and RFS in patients, and represents a diagnostic and prognostic biomarker for patients with pancreatic cancer.Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specific role of TYMS in pancreatic cancer has not been identified. This study was designed to clarify the diagnostic and prognostic significance of TYMS in pancreatic cancer.The Cancer Genome Atlas (TCGA) database was used to compare TYMS expression in pancreatic cancer, and ROC curve analysis was used to investigate its diagnostic value. The correlation between clinical characteristics and TYMS expression was analyzed, and the prognostic value of TYMS expression in the patients with pancreatic cancer was assessed by Kaplan-Meier curves and Cox analysis.TYMS was upregulated in pancreatic cancer and associated with poor overall survival (OS) and recurrence-free survival (RFS). Univariate and multivariate survival analysis demonstrated that TYMS is an independent risk factor for OS and RFS in patients with pancreatic cancer.The upregulation of TYMS in pancreatic cancer leads to unfavorable OS and RFS in patients, and represents a diagnostic and prognostic biomarker for patients with pancreatic cancer. Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specific role of TYMS in pancreatic cancer has not been identified. This study was designed to clarify the diagnostic and prognostic significance of TYMS in pancreatic cancer. The Cancer Genome Atlas (TCGA) database was used to compare TYMS expression in pancreatic cancer, and ROC curve analysis was used to investigate its diagnostic value. The correlation between clinical characteristics and TYMS expression was analyzed, and the prognostic value of TYMS expression in the patients with pancreatic cancer was assessed by Kaplan–Meier curves and Cox analysis. TYMS was upregulated in pancreatic cancer and associated with poor overall survival (OS) and recurrence-free survival (RFS). Univariate and multivariate survival analysis demonstrated that TYMS is an independent risk factor for OS and RFS in patients with pancreatic cancer. The upregulation of TYMS in pancreatic cancer leads to unfavorable OS and RFS in patients, and represents a diagnostic and prognostic biomarker for patients with pancreatic cancer. |
| Author | Jiao, Yan Liu, Bin Ji, Bai Fu, Zhuo Jia, Baoxing Li, Yanqing |
| AuthorAffiliation | b Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University c Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China a Department of Hand and Foot Surgery, The First Hospital of Jilin University |
| AuthorAffiliation_xml | – name: b Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University – name: a Department of Hand and Foot Surgery, The First Hospital of Jilin University – name: c Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China |
| Author_xml | – sequence: 1 givenname: Zhuo surname: Fu fullname: Fu, Zhuo organization: Department of Hand and Foot Surgery, The First Hospital of Jilin University – sequence: 2 givenname: Yan surname: Jiao fullname: Jiao, Yan organization: Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University – sequence: 3 givenname: Yanqing surname: Li fullname: Li, Yanqing organization: Department of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, PR China – sequence: 4 givenname: Bai surname: Ji fullname: Ji, Bai organization: Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University – sequence: 5 givenname: Baoxing surname: Jia fullname: Jia, Baoxing organization: Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University – sequence: 6 givenname: Bin surname: Liu fullname: Liu, Bin organization: Department of Hand and Foot Surgery, The First Hospital of Jilin University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31861032$$D View this record in MEDLINE/PubMed |
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| References_xml | – volume: 100 start-page: 57 year: 2000 ident: R3-20230915 article-title: The hallmark of cancer publication-title: Cell doi: 10.1016/S0092-8674(00)81683-9 – volume: 22 start-page: 9694 year: 2016 ident: R1-20230915 article-title: Epidemiology of pancreatic cancer publication-title: World J Gastroenterol doi: 10.3748/wjg.v22.i44.9694 – volume: 14 start-page: e0211291 year: 2019 ident: R13-20230915 article-title: Aberrant FAM64A mRNA expression is an independent predictor of poor survival in pancreatic cancer publication-title: PLoS One doi: 10.1371/journal.pone.0211291 – volume: 137 start-page: 1397 year: 2015 ident: R19-20230915 article-title: Thymidylate synthase expression in circulating tumor cells: a new tool to predict 5-fluorouracil resistance in metastatic colorectal cancer patients publication-title: Int J Cancer doi: 10.1002/ijc.29495 – volume: 6 start-page: 8377 year: 2015 ident: R6-20230915 article-title: Overexpression of thymidylate synthase (TYMS) is associated with aggressive tumor features and early PSA recurrence in prostate cancer publication-title: Oncotarget doi: 10.18632/oncotarget.3107 – volume: 64 start-page: 721 year: 1995 ident: R5-20230915 article-title: The catalytic mechanism and structure of thymidylate synthase publication-title: Annu Rev Biochem doi: 10.1146/annurev.bi.64.070195.003445 – volume: 10 start-page: 6003 year: 2018 ident: R12-20230915 article-title: High EIF2B5 mRNA expression and its prognostic significance in liver cancer: a study based on the TCGA and GEO database publication-title: Cancer Manag Res doi: 10.2147/CMAR.S185459 – volume: 11 start-page: 3523 year: 2015 ident: R18-20230915 article-title: Expression of ERCC1, TYMS, RRM1, TUBB3, non-muscle myosin II, myoglobin and MyoD1 in lung adenocarcinoma pleural effusions predicts survival in patients receiving platinum-based chemotherapy publication-title: Mol Med Rep doi: 10.3892/mmr.2014.3141 – volume: 65 start-page: 227 year: 2018 ident: R4-20230915 article-title: TYMS 2R3R polymorphism and DPYD [IVS]14+1G>A gene mutation in Mexican colorectal cancer patients publication-title: Acta Biochim Pol doi: 10.18388/abp.2017_2338 – volume: 12 start-page: 1 year: 2011 ident: R9-20230915 article-title: pROC: an open-source package for R and S+ to analyze and compare ROC curves publication-title: Bmc Bioinformatics doi: 10.1186/1471-2105-12-77 – volume: 10 start-page: 937 year: 2015 ident: R15-20230915 article-title: Prognostic significance of the mRNA expression of ERCC1, RRM1, TUBB3 and TYMS genes in patients with non-small cell lung cancer publication-title: Exp Ther Med doi: 10.3892/etm.2015.2636 – volume: 1 start-page: 12 year: 2012 ident: R7-20230915 article-title: R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria publication-title: Computing – volume: 9 start-page: e106397 year: 2014 ident: R8-20230915 article-title: RTCGAToolbox: a new tool for exporting TCGA firehose data publication-title: Plos One doi: 10.1371/journal.pone.0106397 – volume: 24 start-page: 2047 year: 2018 ident: R2-20230915 article-title: Challenges in diagnosis of pancreatic cancer publication-title: World J Gastroenterol doi: 10.3748/wjg.v24.i19.2047 – volume: 13 start-page: 3387 year: 2017 ident: R17-20230915 article-title: MicroRNA-330 inhibited cell proliferation and enhanced chemosensitivity to 5-fluorouracil in colorectal cancer by directly targeting thymidylate synthase publication-title: Oncol Lett doi: 10.3892/ol.2017.5895 – volume: 97 start-page: 353 year: 2000 ident: R11-20230915 article-title: Modeling survival data: extending the cox model publication-title: Technometrics – volume: 122 start-page: 152 year: 2018 ident: R16-20230915 article-title: Expression of tumour progression-associated genes in circulating tumour cells of patients at different stages of prostate cancer publication-title: BJU Int doi: 10.1111/bju.14200 – volume: 388 start-page: 73 year: 2016 ident: R21-20230915 article-title: Pancreatic cancer publication-title: Lancet doi: 10.1016/S0140-6736(16)00141-0 – volume: 10 start-page: 564 year: 2016 ident: R14-20230915 article-title: Autoantibodies against TYMS and PDLIM1 proteins detected as circulatory signatures in Indian breast cancer patients publication-title: Proteomics Clin Appl doi: 10.1002/prca.201500138 – volume: 8 start-page: 77734 year: 2017 ident: R20-20230915 article-title: Pyrimidine metabolic rate limiting enzymes in poorly-differentiated hepatocellular carcinoma are signature genes of cancer stemness and associated with poor prognosis publication-title: Oncotarget doi: 10.18632/oncotarget.20774 |
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| SubjectTerms | Biomarkers, Tumor - metabolism Case-Control Studies China - epidemiology Female Humans Male Middle Aged Observational Study Pancreatic Neoplasms - diagnosis Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Prognosis Thymidylate Synthase - metabolism Up-Regulation |
| Title | TYMS presents a novel biomarker for diagnosis and prognosis in patients with pancreatic cancer |
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