TYMS presents a novel biomarker for diagnosis and prognosis in patients with pancreatic cancer

Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specifi...

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Veröffentlicht in:Medicine (Baltimore) Jg. 98; H. 51; S. e18487
Hauptverfasser: Fu, Zhuo, Jiao, Yan, Li, Yanqing, Ji, Bai, Jia, Baoxing, Liu, Bin
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wolters Kluwer Health 01.12.2019
Schlagworte:
Biomarkers, Tumor - metabolism
Case-Control Studies
China - epidemiology
Female
Humans
Male
Middle Aged
Observational Study
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - metabolism
Pancreatic Neoplasms - mortality
Prognosis
Thymidylate Synthase - metabolism
Up-Regulation
China
ISSN:0025-7974, 1536-5964, 1536-5964
Online-Zugang:Volltext
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Zusammenfassung:Pancreatic cancer is one of the most malignant tumors worldwide. DNA replication plays a critical role in the occurrence and development of pancreatic cancer. TYMS encodes thymidylate synthase, which is important for DNA synthesis. The TYMS gene has been assessed in some tumors. However, the specific role of TYMS in pancreatic cancer has not been identified. This study was designed to clarify the diagnostic and prognostic significance of TYMS in pancreatic cancer.The Cancer Genome Atlas (TCGA) database was used to compare TYMS expression in pancreatic cancer, and ROC curve analysis was used to investigate its diagnostic value. The correlation between clinical characteristics and TYMS expression was analyzed, and the prognostic value of TYMS expression in the patients with pancreatic cancer was assessed by Kaplan-Meier curves and Cox analysis.TYMS was upregulated in pancreatic cancer and associated with poor overall survival (OS) and recurrence-free survival (RFS). Univariate and multivariate survival analysis demonstrated that TYMS is an independent risk factor for OS and RFS in patients with pancreatic cancer.The upregulation of TYMS in pancreatic cancer leads to unfavorable OS and RFS in patients, and represents a diagnostic and prognostic biomarker for patients with pancreatic cancer.
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ISSN:0025-7974
1536-5964
1536-5964
DOI:10.1097/MD.0000000000018487