The sensitivity and specificity of thyroglobulin concentration using repeated measures of urinary iodine excretion

Purpose Iodine deficiency affects 30% of populations worldwide. The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess. Tg is considered as a sensitive index of iodine status in groups of children and adults, but its usefulness for individuals is unknown....

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Veröffentlicht in:European journal of nutrition Jg. 57; H. 4; S. 1313 - 1320
Hauptverfasser: Ma, Zheng F., Venn, Bernard J., Manning, Patrick J., Cameron, Claire M., Skeaff, Sheila A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2018
Springer Nature B.V
Schlagworte:
Adolescent
Adult
adults
Biomarkers
Biomarkers - blood
Biomarkers - urine
blood
blood sampling
Chemistry
Chemistry and Materials Science
Children
Creatinine
Creatinine - urine
Cross-Sectional Studies
Diagnostic Tests, Routine - standards
Excretion
Female
Health risk assessment
Humans
Iodides
Iodine
Iodine - deficiency
Iodine - urine
Male
Medical diagnosis
New Zealand
Nutrition
Nutritional Status
Original Contribution
reference standards
ROC Curve
Thyroglobulin
Thyroglobulin - blood
Thyroid
Thyroid-stimulating hormone
thyrotropin
Thyrotropin - blood
Thyroxine
Urine
Within-subjects design
Young Adult
New Zealand
Diagnostic
Adult
Biomarker
Iodine deficiency
Thyroglobulin
ISSN:1436-6207, 1436-6215, 1436-6215
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Zusammenfassung:Purpose Iodine deficiency affects 30% of populations worldwide. The amount of thyroglobulin (Tg) in blood increases in iodine deficiency and also in iodine excess. Tg is considered as a sensitive index of iodine status in groups of children and adults, but its usefulness for individuals is unknown. The aim of this study was to determine the diagnostic performance of Tg as an index of iodine status in individual adults. Methods Adults aged 18–40 years ( n  = 151) provided five spot urine samples for the measurement of urinary iodine concentration expressed as μg/L (UIC), μg/g of creatinine (I:Cre), and μg/day (estimated UIE); the mean of the five samples was used as the reference standard. Participants also provided a blood sample for the determination of Tg, thyroid-stimulating hormone (TSH), and free thyroxine (FT4). Results The median of UIC, I:Cre, estimated UIE, and Tg was 72 (range 16–350) μg/L, 90 (range 33–371) μg/g, 129 (range 41–646) μg/day, and 16.4 (range 0.8–178.9) μg/L, respectively. Using Tg cut-offs of >10, >11, >13, and >15 μg/L, the sensitivity and specificity for UIC, I:Cre, and estimated UIE ranged from 52 to 79% and 20–48%, respectively, below the acceptable value of ≥80%. Furthermore, receiver-operating characteristic (ROC) curves for Tg using the three measurements of urinary iodine were situated close to the chance line and the area under the curve ranged from 0.49 to 0.52. Conclusions The results from this cross-sectional study indicate that Tg has low sensitivity and specificity to repeated measures of urinary iodine excretion. Further studies are still needed to investigate the usefulness of Tg as a biomarker of individual iodine status.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-017-1410-6