The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF)

Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study...

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Published in:	Journal of dentistry Vol. 41; pp. S22 - S28
Main Authors:	Yin, W, Hu, D.Y, Li, X, Fan, X, Zhang, Y.P, Pretty, I.A, Mateo, L.R, Cummins, D, Ellwood, R.P
Format:	Journal Article
Language:	English
Published:	England 01.08.2013
Subjects:	Adolescent Arginine - therapeutic use Calcium Carbonate - therapeutic use Cariostatic Agents - therapeutic use Child Dental Caries - pathology Dental Caries - prevention & control Dental Enamel - drug effects Dental Enamel - pathology Dentifrices - therapeutic use Dentistry Double-Blind Method Female Fluorescence Fluorides - therapeutic use Follow-Up Studies Humans Image Processing, Computer-Assisted - methods Light Male Phosphates - therapeutic use Sodium Fluoride - therapeutic use Tooth Remineralization - methods Treatment Outcome Caries Fluoride Arrest Arginine Enamel Dentifrice Reversal Lesions
ISSN:	0300-5712, 1879-176X, 1879-176X
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Abstract	Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study design Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use. Results 438 participants (initial age 9–13 years (mean 11.1 ± 0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean Δ Q (mm2 %), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the Δ Q values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant ( p < 0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months. Conclusion The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone.
AbstractList	To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone.OBJECTIVETo compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone.Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use.STUDY DESIGNParticipants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use.438 participants (initial age 9-13 years (mean 11.1±0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean ΔQ (mm(2)%), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the ΔQ values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant (p<0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months.RESULTS438 participants (initial age 9-13 years (mean 11.1±0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean ΔQ (mm(2)%), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the ΔQ values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant (p<0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months.The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone.CONCLUSIONThe new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone. To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use. 438 participants (initial age 9-13 years (mean 11.1±0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean ΔQ (mm(2)%), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the ΔQ values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant (p<0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months. The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone. Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone. Study design Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use. Results 438 participants (initial age 9–13 years (mean 11.1 ± 0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean Δ Q (mm2 %), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the Δ Q values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant ( p < 0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months. Conclusion The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone.
Author	Ellwood, R.P Cummins, D Zhang, Y.P Li, X Mateo, L.R Yin, W Hu, D.Y Fan, X Pretty, I.A
Author_xml	– sequence: 1 fullname: Yin, W – sequence: 2 fullname: Hu, D.Y – sequence: 3 fullname: Li, X – sequence: 4 fullname: Fan, X – sequence: 5 fullname: Zhang, Y.P – sequence: 6 fullname: Pretty, I.A – sequence: 7 fullname: Mateo, L.R – sequence: 8 fullname: Cummins, D – sequence: 9 fullname: Ellwood, R.P
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Snippet	Abstract Objective To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and... To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally...
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SubjectTerms	Adolescent Arginine - therapeutic use Calcium Carbonate - therapeutic use Cariostatic Agents - therapeutic use Child Dental Caries - pathology Dental Caries - prevention & control Dental Enamel - drug effects Dental Enamel - pathology Dentifrices - therapeutic use Dentistry Double-Blind Method Female Fluorescence Fluorides - therapeutic use Follow-Up Studies Humans Image Processing, Computer-Assisted - methods Light Male Phosphates - therapeutic use Sodium Fluoride - therapeutic use Tooth Remineralization - methods Treatment Outcome
Title	The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF)
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