Metabolic Acidosis Improves Airway Conductance in Patients with Asthma

The objective was to investigate whether acute metabolic acidosis could cause bronchodilation in patients with asthma. Twelve patients with asthma (8 females, mean age 39 (± SD 12) years, forced expiratory volume in 1 second [FEV1] 93 [±9] % predicted, PC20 1.9 (±1.0) mg/mL) participated in a double...

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Bibliographic Details
Published in:	The Journal of asthma Vol. 46; no. 7; pp. 656 - 658
Main Authors:	Brijker, F., Van Den Elshout, F. J.J., Bosch, F. H., Heijdra, Y. F., Folgering, H. Th.M.
Format:	Journal Article
Language:	English
Published:	England Informa UK Ltd 01.01.2009 Taylor & Francis
Subjects:	Acidosis - chemically induced Administration, Oral Adult Airway Resistance - drug effects Airway Resistance - physiology Ammonium Chloride - administration & dosage Ammonium Chloride - pharmacology Ammonium Chloride - therapeutic use asthma Asthma - drug therapy Asthma - physiopathology Bronchial Hyperreactivity - drug therapy Bronchial Hyperreactivity - physiopathology bronchodilation Double-Blind Method Female Forced Expiratory Volume - drug effects Forced Expiratory Volume - physiology Humans Hydrogen-Ion Concentration - drug effects In Vitro Techniques Male metabolic acidosis Middle Aged Peak Expiratory Flow Rate - drug effects Peak Expiratory Flow Rate - physiology specific airway conductance Treatment Outcome
ISSN:	0277-0903, 1532-4303, 1532-4303
Online Access:	Get full text
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