Acquired Reactive Perforating Collagenosis Complicated by Diabetes Mellitus and Hypertension: A Case Report

Introduction: Acquired reactive perforating collagenosis (ARPC) is a rare cutaneous disorder frequently associated with systemic diseases such as diabetes mellitus and chronic kidney disease. Its diagnosis remains challenging due to clinical overlap with other perforating dermatoses, necessitating a...

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Vydáno v:Case reports in dermatology Ročník 17; číslo 1; s. 143 - 149
Hlavní autoři: Zhang, Meng, Chu, Ruiqi, Shen, Junping, Liu, Chunmei, Wang, Yanan, Zhang, Shun, Ren, Xiangxiang
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland S. Karger AG 17.04.2025
Karger Publishers
Témata:
Case and Review
Acquired reactive perforating collagenosis
Diagnosis
Dermatoscopy
Collagen disease
ISSN:1662-6567, 1662-6567
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Shrnutí:Introduction: Acquired reactive perforating collagenosis (ARPC) is a rare cutaneous disorder frequently associated with systemic diseases such as diabetes mellitus and chronic kidney disease. Its diagnosis remains challenging due to clinical overlap with other perforating dermatoses, necessitating advanced diagnostic tools for confirmation. Case Presentation: A 55-year-old male with a 15-year history of diabetes mellitus and hypertension developed progressively pruritic papules and nodules on both lower limbs over 2 months. Initial misdiagnosis as a fungal infection led to unsuccessful antifungal therapy. Dermatoscopy revealed keratotic plugs with peripheral erythema, while histopathology demonstrated transepidermal elimination of degenerated collagen, confirming ARPC. Topical retinoic acid cream achieved marked symptomatic relief. Conclusion: This case highlights ARPC’s strong association with metabolic comorbidities and underscores the necessity of dermatoscopic and histopathological evaluation to avoid diagnostic pitfalls. The therapeutic success of topical retinoids in resource-constrained settings reinforces their role as a pragmatic first-line intervention. Clinicians should consider ARPC in patients with chronic pruritic eruptions and systemic metabolic disorders, advocating for multidisciplinary collaboration to address underlying comorbidities.
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ISSN:1662-6567
1662-6567
DOI:10.1159/000545693