The JAMM motif of human deubiquitinase Poh1 is essential for cell viability

Poh1 deubiquitinase activity is required for proteolytic processing of polyubiquitinated substrates by the 26S proteasome, linking deubiquitination to complete substrate degradation. Poh1 RNA interference (RNAi) in HeLa cells resulted in a reduction in cell viability and an increase in polyubiquitin...

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Bibliographic Details

Published in:	Molecular cancer therapeutics Vol. 6; no. 1; p. 262
Main Authors:	Gallery, Melissa, Blank, Jonathan L, Lin, Yinghui, Gutierrez, Juan A, Pulido, Jacqueline C, Rappoli, David, Badola, Sunita, Rolfe, Mark, Macbeth, Kyle J
Format:	Journal Article
Language:	English
Published:	United States 01.01.2007
Subjects:	Amino Acid Motifs Cell Survival HeLa Cells Humans Mutant Proteins - metabolism Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - deficiency Proteasome Endopeptidase Complex - metabolism RNA Interference Trans-Activators - chemistry Trans-Activators - deficiency Trans-Activators - metabolism Ubiquitin - metabolism
ISSN:	1535-7163
Online Access:	Get more information
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