Neutrophils create a fertile soil for metastasis
Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellul...
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| Vydáno v: | Cancer cell Ročník 39; číslo 3; s. 301 |
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| Hlavní autoři: | , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
08.03.2021
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| ISSN: | 1878-3686, 1878-3686 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
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| Shrnutí: | Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis. |
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| Bibliografie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23 |
| ISSN: | 1878-3686 1878-3686 |
| DOI: | 10.1016/j.ccell.2021.01.009 |