Cytoplasmic Expression of Human Telomerase Catalytic Protein (hTERT) in Neutrophils: An Immunoelectron Microscopy Study

Human telomerase comprises a catalytic protein subunit (hTERT) and an RNA subunit (hTR). Telomerase extends chromosome ends in compensation for the attrition of the telomeres during replication. In this work, the authors explore the expression of hTERT and hTR in neutrophils, respectively by immunoc...

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Published in:Ultrastructural pathology Vol. 32; no. 5; pp. 178 - 183
Main Authors: Lepreux, Sébastien, Doudnikoff, Evelyne, Aubert, Incarnation, Bioulac-Sage, Paulette, Bloch, Bertrand, Martin-Negrier, Marie-Laure
Format: Journal Article
Language:English
Published: England Informa UK Ltd 01.01.2008
Taylor & Francis
Subjects:
Cytoplasm - enzymology
Cytoplasm - ultrastructure
hTERT
Humans
immunoelectron microscopy
In Situ Hybridization
Liver - enzymology
Liver - ultrastructure
Microscopy, Immunoelectron
neutrophils
Neutrophils - enzymology
Neutrophils - ultrastructure
RNA
RNA, Long Noncoding
RNA, Untranslated - analysis
telomerase
Telomerase - analysis
Urinary Bladder - enzymology
Urinary Bladder - ultrastructure
ISSN:0191-3123, 1521-0758, 1521-0758
Online Access:Get full text
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Summary:Human telomerase comprises a catalytic protein subunit (hTERT) and an RNA subunit (hTR). Telomerase extends chromosome ends in compensation for the attrition of the telomeres during replication. In this work, the authors explore the expression of hTERT and hTR in neutrophils, respectively by immunochemistry techniques and in situ hybridization. hTERT was strongly expressed in neutrophils cytoplasm. The ultrastructural study showed that the gold particles were not associated with specific organelles but scattered in the cytosol. hTR was not expressed. hTERT is expressed in the cytoplasm of neutrophils, but its roles-eventually extratelomeric effects-remain to be elucidated.
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ISSN:0191-3123
1521-0758
1521-0758
DOI:10.1080/01913120802034504