Cytoplasmic Expression of Human Telomerase Catalytic Protein (hTERT) in Neutrophils: An Immunoelectron Microscopy Study

Human telomerase comprises a catalytic protein subunit (hTERT) and an RNA subunit (hTR). Telomerase extends chromosome ends in compensation for the attrition of the telomeres during replication. In this work, the authors explore the expression of hTERT and hTR in neutrophils, respectively by immunoc...

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Veröffentlicht in:Ultrastructural pathology Jg. 32; H. 5; S. 178 - 183
Hauptverfasser: Lepreux, Sébastien, Doudnikoff, Evelyne, Aubert, Incarnation, Bioulac-Sage, Paulette, Bloch, Bertrand, Martin-Negrier, Marie-Laure
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Informa UK Ltd 01.01.2008
Taylor & Francis
Schlagworte:
Cytoplasm - enzymology
Cytoplasm - ultrastructure
hTERT
Humans
immunoelectron microscopy
In Situ Hybridization
Liver - enzymology
Liver - ultrastructure
Microscopy, Immunoelectron
neutrophils
Neutrophils - enzymology
Neutrophils - ultrastructure
RNA
RNA, Long Noncoding
RNA, Untranslated - analysis
telomerase
Telomerase - analysis
Urinary Bladder - enzymology
Urinary Bladder - ultrastructure
ISSN:0191-3123, 1521-0758, 1521-0758
Online-Zugang:Volltext
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Zusammenfassung:Human telomerase comprises a catalytic protein subunit (hTERT) and an RNA subunit (hTR). Telomerase extends chromosome ends in compensation for the attrition of the telomeres during replication. In this work, the authors explore the expression of hTERT and hTR in neutrophils, respectively by immunochemistry techniques and in situ hybridization. hTERT was strongly expressed in neutrophils cytoplasm. The ultrastructural study showed that the gold particles were not associated with specific organelles but scattered in the cytosol. hTR was not expressed. hTERT is expressed in the cytoplasm of neutrophils, but its roles-eventually extratelomeric effects-remain to be elucidated.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0191-3123
1521-0758
1521-0758
DOI:10.1080/01913120802034504