Ventilator-induced lung injury is mediated by the NLRP3 inflammasome

The innate immune response is important in ventilator-induced lung injury (VILI) but the exact pathways involved are not elucidated. The authors studied the role of the intracellular danger sensor NLRP3 inflammasome. NLRP3 inflammasome gene expression was analyzed in respiratory epithelial cells and...

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Bibliographic Details
Published in:	Anesthesiology (Philadelphia) Vol. 116; no. 5; p. 1104
Main Authors:	Kuipers, Maria T, Aslami, Hamid, Janczy, John R, van der Sluijs, Koenraad F, Vlaar, Alexander P J, Wolthuis, Esther K, Choi, Goda, Roelofs, Joris J T H, Flavell, Richard A, Sutterwala, Fayyaz S, Bresser, Paul, Leemans, Jaklien C, van der Poll, Tom, Schultz, Marcus J, Wieland, Catharina W
Format:	Journal Article
Language:	English
Published:	United States 01.05.2012
Subjects:	Animals Bronchoalveolar Lavage Fluid - chemistry Carrier Proteins - genetics Carrier Proteins - physiology Caspase 1 - metabolism Cytokines - blood Cytokines - metabolism Enzyme Activation - physiology Epithelial Cells - metabolism Glyburide - pharmacology Humans Inflammasomes - genetics Macrophages, Alveolar - metabolism Mice Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration NLR Family, Pyrin Domain-Containing 3 Protein Organ Size - physiology Receptors, Interleukin-1 - antagonists & inhibitors Respiration, Artificial RNA, Messenger - biosynthesis RNA, Messenger - genetics Tidal Volume - physiology Up-Regulation - physiology Uric Acid - metabolism Ventilator-Induced Lung Injury - genetics Ventilator-Induced Lung Injury - pathology
ISSN:	1528-1175, 1528-1175
Online Access:	Get more information
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