Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition

Despite intense research, treatment options for patients with mesothelioma are limited and offer only modest survival advantage. We screened a large panel of compounds in multiple mesothelioma models and correlated sensitivity with a range of molecular features to detect biomarkers of drug response....

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Veröffentlicht in:	Clinical cancer research Jg. 24; H. 1; S. 84
Hauptverfasser:	Quispel-Janssen, Josine M, Badhai, Jitendra, Schunselaar, Laurel, Price, Stacey, Brammeld, Jonathan, Iorio, Francesco, Kolluri, Krishna, Garnett, Matthew, Berns, Anton, Baas, Paul, McDermott, Ultan, Neefjes, Jacques, Alifrangis, Constantine
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2018
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - genetics Cell Line, Tumor Cell Proliferation Cell Survival - drug effects Cell Survival - genetics Disease Models, Animal Drug Resistance, Neoplasm Drug Screening Assays, Antitumor ErbB Receptors - antagonists & inhibitors Female Fibroblast Growth Factors - metabolism Gene Amplification Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Mesothelioma - drug therapy Mesothelioma - genetics Mesothelioma - metabolism Mesothelioma - pathology Mesothelioma, Malignant Mice Pharmacogenetics - methods Pleural Neoplasms - drug therapy Pleural Neoplasms - genetics Pleural Neoplasms - metabolism Pleural Neoplasms - pathology RNA Interference Signal Transduction Tumor Suppressor Proteins - metabolism Ubiquitin Thiolesterase - metabolism Xenograft Model Antitumor Assays
ISSN:	1557-3265, 1557-3265
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