Expanding our understanding of Guillain–Barré syndrome: Recent advances and clinical implications

Guillain–Barré syndrome (GBS) is a rare yet potentially life‐threatening disorder of the peripheral nervous system (PNS), characterized by substantial clinical heterogeneity. Although classified as an autoimmune disease, the immune mechanisms underpinning distinct GBS subtypes remain largely elusive...

Full description

Saved in:
Bibliographic Details
Published in:European journal of immunology Vol. 54; no. 11; pp. e2250336 - n/a
Main Authors: Ripellino, Paolo, Schreiner, Bettina, Latorre, Daniela
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 01.11.2024
Subjects:
Acute inflammatory demyelinating polyradiculoneuropathy (AIDP)
Animals
Autoantibodies - immunology
Autoimmune diseases
Autoimmunity
Autoreactive T cells
Guillain-Barre Syndrome - immunology
Guillain-Barre Syndrome - therapy
Guillain–Barré syndrome
Humans
Immunopathology
Lymphocytes T
Nervous system
T-Lymphocytes - immunology
Autoimmunity
Acute inflammatory demyelinating polyradiculoneuropathy (AIDP)
Immunopathology
Guillain–Barré syndrome
Autoreactive T cells
ISSN:0014-2980, 1521-4141, 1521-4141
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Guillain–Barré syndrome (GBS) is a rare yet potentially life‐threatening disorder of the peripheral nervous system (PNS), characterized by substantial clinical heterogeneity. Although classified as an autoimmune disease, the immune mechanisms underpinning distinct GBS subtypes remain largely elusive. Traditionally considered primarily antibody‐mediated, the pathophysiology of GBS lacks clarity, posing challenges in the development of targeted and effective treatments. Nevertheless, recent investigations have substantially expanded our understanding of the disease, revealing an involvement of autoreactive T cell immunity in a major subtype of GBS patients and opening new biomedical perspectives. This review highlights these discoveries and offers a comprehensive overview of current knowledge about GBS, including ongoing challenges in disease management. Guillain–Barré syndrome (GBS) is a rare and heterogeneous disorder of the peripheral nervous system. Traditionally considered antibody‐mediated, recent research highlights the involvement of autoreactive T cells in its immunopathology. This review examines recent discoveries and provides a comprehensive overview of current knowledge, challenges in disease management, and new biomedical perspectives.
Bibliography:Paolo Ripellino and Bettina Schreiner are contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:0014-2980
1521-4141
1521-4141
DOI:10.1002/eji.202250336