Alterations of the Gut Microbiome Associated With the Treatment of Hyperuricaemia in Male Rats

Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota is associated with hyperuricaemia and has also been demonstrated to play significant roles in the effects of drug therapy. This study used Illumina MiSeq sequencing to...

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Vydané v:Frontiers in microbiology Ročník 9; s. 2233
Hlavní autori: Yu, Yiran, Liu, Qiuping, Li, Haichang, Wen, Chengping, He, Zhixing
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 19.09.2018
Predmet:
allopurinol
benzbromarone
gut microbiome
hyperuricaemia
Illumina MiSeq
Microbiology
gut microbiome
Illumina MiSeq
benzbromarone
allopurinol
hyperuricaemia
ISSN:1664-302X, 1664-302X
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Shrnutí:Hyperuricaemia is an important risk factor for many diseases including gout, hypertension, and type II diabetes. The gut microbiota is associated with hyperuricaemia and has also been demonstrated to play significant roles in the effects of drug therapy. This study used Illumina MiSeq sequencing to explore alterations of the gut microbiome associated with allopurinol and benzbromarone treatment in the male rat with hyperuricaemia. After drug treatment, both allopurinol and benzbromarone caused an increase of the genera and and a decrease of the genera and . In addition, allopurinol and benzbromarone caused respective unique changes in genera. The genera , , and specifically decreased due to allopurinol treatment. Decreased and and increased were caused by benzbromarone treatment. The PICRUST analysis indicated that allopurinol renovated the disorder of nucleotide metabolism and benzbromarone renovated the disorder of lipid metabolism in the gut microbiota of male rats with hyperuricaemia. These findings demonstrated that the gut microbiota may be altered by the treatment of hyperuricaemia with allopurinol and benzbromarone in male rats. Such alterations of the gut microbiota could be considered as indicators of the effectiveness of drug therapy.
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This article was submitted to Systems Microbiology, a section of the journal Frontiers in Microbiology
Edited by: George Tsiamis, University of Patras, Greece
Reviewed by: Jaime Garcia-Mena, Centro de Investigación y de Estudios Avanzados (CINVESTAV), Mexico; Spyridon Ntougias, Democritus University of Thrace, Greece
These authors have contributed equally to this work
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2018.02233