A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

Purpose This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy- d -glucose (2DG) in combination with docetaxel, in patients with advanced solid tumors. Methods A modified accelerated titration design was us...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology Jg. 71; H. 2; S. 523 - 530
Hauptverfasser:	Raez, Luis E., Papadopoulos, Kyriakos, Ricart, Alejandro D., Chiorean, E. Gabriella, DiPaola, Robert S., Stein, Mark N., Rocha Lima, Caio M., Schlesselman, James J., Tolba, Khaled, Langmuir, Virginia K., Kroll, Stewart, Jung, Donald T., Kurtoglu, Metin, Rosenblatt, Joseph, Lampidis, Theodore J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Berlin/Heidelberg Springer-Verlag 01.02.2013 Springer Springer Nature B.V
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Blood Glucose - analysis Cancer Research Clinical Trial Report Deoxyglucose - administration & dosage Deoxyglucose - adverse effects Deoxyglucose - therapeutic use Electrocardiography - drug effects Female Gynecology. Andrology. Obstetrics Humans Male Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasms - drug therapy Oncology Pharmacology. Drug treatments Pharmacology/Toxicology Pneumology Taxoids - administration & dosage Taxoids - adverse effects Taxoids - therapeutic use Tumors Tumors of the respiratory system and mediastinum Phase I Head and neck cancers Lung cancer Docetaxel Breast cancer 2-Deoxy Glucose Antineoplastic agent Solid tumor Breast disease Dose escalation Bronchopulmonary Increasing dose Taxane derivatives ENT disease Bronchus disease Clinical trial Advanced stage Antimitotic Human Lung disease Respiratory disease Malignant tumor Mammary gland diseases 2-Deoxy-D-Glucose Head and neck cancer Cancer
ISSN:	0344-5704, 1432-0843, 1432-0843
Online-Zugang:	Volltext
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