A Potential Role for Creatine in Drug Abuse?

Supplemental creatine has been promoted for its positive health effects and is best known for its use by athletes to increase muscle mass. In addition to its role in physical performance, creatine supplementation has protective effects on the brain in models of neuronal damage and also alters mood s...

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Vydané v:Molecular neurobiology Ročník 44; číslo 2; s. 136 - 141
Hlavní autori: D’Anci, Kristen E., Allen, Patricia J., Kanarek, Robin B.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Humana Press Inc 01.10.2011
Springer Nature B.V
Predmet:
Addictive behaviors
Amino acids
Biomedical and Life Sciences
Biomedicine
Brain - metabolism
Brain - physiopathology
Brain damage
Brain Injuries - drug therapy
Cell Biology
Creatine - administration & dosage
Creatine - metabolism
Creatine - therapeutic use
Depressive Disorder - drug therapy
Depressive Disorder - physiopathology
Dietary Supplements
Drug abuse
Energy Metabolism
Humans
Mental depression
Molecular Structure
Neurobiology
Neurology
Neurosciences
Post traumatic stress disorder
Substance-Related Disorders - drug therapy
Substance-Related Disorders - physiopathology
Magnetic resonance spectroscopy
Drug abuse
Traumatic brain injury
Nutrition
Post-traumatic stress disorder
Depression
Creatine
Stress
ISSN:0893-7648, 1559-1182, 1559-1182
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Shrnutí:Supplemental creatine has been promoted for its positive health effects and is best known for its use by athletes to increase muscle mass. In addition to its role in physical performance, creatine supplementation has protective effects on the brain in models of neuronal damage and also alters mood state and cognitive performance. Creatine is found in high protein foods, such as fish or meat, and is also produced endogenously from the biosynthesis of arginine, glycine, and methionine. Changes in brain creatine levels, as measured using magnetic resonance spectroscopy, are seen in individuals exposed to drugs of abuse and depressed individuals. These changes in brain creatine indicate that energy metabolism differs in these populations relative to healthy individuals. Recent work shows that creatine supplementation has the ability to function in a manner similar to antidepressant drugs and can offset negative consequences of stress. These observations are important in relation to addictive behaviors as addiction is influenced by psychological factors such as psychosocial stress and depression. The significance of altered brain levels of creatine in drug-exposed individuals and the role of creatine supplementation in models of drug abuse have yet to be explored and represent gaps in the current understanding of brain energetics and addiction.
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ISSN:0893-7648
1559-1182
1559-1182
DOI:10.1007/s12035-011-8176-2