Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking

Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries, particularly ventral tegmental area (VTA) dopamine neurons. How cocaine exposures act on midbrain dopamine neurons to precipitate addiction-releva...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 368; no. 6487; p. 197
Main Authors:	Lepack, Ashley E, Werner, Craig T, Stewart, Andrew F, Fulton, Sasha L, Zhong, Ping, Farrelly, Lorna A, Smith, Alexander C W, Ramakrishnan, Aarthi, Lyu, Yang, Bastle, Ryan M, Martin, Jennifer A, Mitra, Swarup, O'Connor, Richard M, Wang, Zi-Jun, Molina, Henrik, Turecki, Gustavo, Shen, Li, Yan, Zhen, Calipari, Erin S, Dietz, David M, Kenny, Paul J, Maze, Ian
Format:	Journal Article
Language:	English
Published:	United States 10.04.2020
Subjects:	Animals Cocaine - adverse effects Cocaine-Related Disorders - genetics Cocaine-Related Disorders - metabolism Cocaine-Related Disorders - psychology Dopamine - metabolism Dopaminergic Neurons - metabolism Drug-Seeking Behavior Gene Expression Regulation Glutamine - metabolism Histones - metabolism Humans Male Mice Mice, Inbred C57BL Neuronal Plasticity Nucleus Accumbens - metabolism Rats Rats, Sprague-Dawley Synaptic Transmission Ventral Tegmental Area - metabolism
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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