Polymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives

The development of polymeric luminescent nanomaterials for biomedical applications has recently attracted a large amount of attention due to the remarkable advantages of these materials compared with small organic dyes and fluorescent inorganic nanomaterials. Among these polymeric luminescent nanoma...

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Published in:Nanoscale Vol. 7; no. 27; p. 11486
Main Authors: Zhang, Xiaoyong, Wang, Ke, Liu, Meiying, Zhang, Xiqi, Tao, Lei, Chen, Yiwang, Wei, Yen
Format: Journal Article
Language:English
Published: England 21.07.2015
Subjects:
Animals
Apoptosis
Biosensing Techniques
Coloring Agents - chemistry
Diagnostic Imaging - methods
Emulsions
Fluorescent Dyes - chemistry
HeLa Cells
Humans
Luminescence
Mice
Micelles
Nanomedicine - methods
Nanoparticles - chemistry
Nanostructures
Organic Chemicals - chemistry
Phase Transition
Polymers - chemistry
ISSN:2040-3372, 2040-3372
Online Access:Get more information
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Summary:The development of polymeric luminescent nanomaterials for biomedical applications has recently attracted a large amount of attention due to the remarkable advantages of these materials compared with small organic dyes and fluorescent inorganic nanomaterials. Among these polymeric luminescent nanomaterials, polymeric luminescent nanomaterials based on dyes with aggregation-induced emission (AIE) properties should be of great research interest due to their unique AIE properties, the designability of polymers and their multifunctional potential. In this review, the recent advances in the design and biomedical applications of polymeric luminescent nanomaterials based on AIE dyes is summarized. Various design strategies for incorporation of these AIE dyes into polymeric systems are included. The potential biomedical applications such as biological imaging, and use in biological sensors and theranostic systems of these polymeric AIE-based nanomaterials have also been highlighted. We trust this review will attract significant interest from scientists from different research fields in chemistry, materials, biology and interdisciplinary areas.
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ISSN:2040-3372
2040-3372
DOI:10.1039/c5nr01444a