Engineered multitargeting exosomes carrying miR-323a-3p for CRC therapy

Colorectal cancer (CRC) is in the forefront of malignancies for its high incidence and mortality. 5-Fluorouracil (5-FU) is one of the most widely used effective drugs for the treatment of CRC. However, there is an urgent need in reducing its systemic side effects and chemoresistance, in order to mak...

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Bibliographic Details
Published in:	International journal of biological macromolecules Vol. 247; p. 125794
Main Authors:	Pang, Yechun, Chen, Xingshi, Xu, Baiying, Zhang, Yuanzhou, Liang, Shunshun, Hu, Jingying, Liu, Rui, Luo, Xiaoying, Wang, Yunfeng
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 30.08.2023
Subjects:	5-fluorouracil (5-FU)-resistance apoptosis cell proliferation colorectal neoplasms CRC therapy cytotoxicity drug therapy EGFR Exosomes fluorouracil miR-323a-3p mortality patients remission thymidylate synthase TYMS xenotransplantation 5-fluorouracil (5-FU)-resistance CRC therapy Exosomes TYMS miR-323a-3p EGFR
ISSN:	0141-8130, 1879-0003, 1879-0003
Online Access:	Get full text
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