Chemical structure and anti-inflammatory effect of polysaccharides obtained from infusion of Sedum dendroideum leaves

Sedum dendroideum is popularly known as balsam and used for treatment of inflammatory disorders. Two polysaccharides (RSBAL-H2O and RSBAL-0.5) were isolated from infusion of its dried leaves, using dialysis at 100kDa cut-off membrane and anion exchange chromatography. Methylation and NMR analyses sh...

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Vydané v:International journal of biological macromolecules Ročník 105; číslo Pt 1; s. 940 - 946
Hlavní autori: Oliveira, Ana Flávia de, Nascimento, Geórgia Erdmann do, Iacomini, Marcello, Cordeiro, Lucimara Mach Côrtes, Cipriani, Thales Ricardo
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Netherlands Elsevier B.V 01.12.2017
Predmet:
anion exchange chromatography
anti-inflammatory activity
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
arabinans
arabinogalactans
Cell Line, Tumor
chemical structure
Cytokines
dialysis
Humans
Immunomodulation - drug effects
immunostimulants
interleukin-10
interleukin-1beta
leaves
macrophages
Macrophages - drug effects
Macrophages - immunology
Macrophages - metabolism
Methylation
nuclear magnetic resonance spectroscopy
Plant Leaves - chemistry
Polysaccharides
Polysaccharides - chemistry
Polysaccharides - pharmacology
secretion
Sedum - chemistry
Sedum dendroideum
tumor necrosis factor-alpha
Cytokines
Sedum dendroideum
Polysaccharides
ISSN:0141-8130, 1879-0003, 1879-0003
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Shrnutí:Sedum dendroideum is popularly known as balsam and used for treatment of inflammatory disorders. Two polysaccharides (RSBAL-H2O and RSBAL-0.5) were isolated from infusion of its dried leaves, using dialysis at 100kDa cut-off membrane and anion exchange chromatography. Methylation and NMR analyses showed that RSBAL-H2O is a highly methyl-esterified homogalacturonan, constituted by (1→4)-α-D-GalA residues, whereas RSBAL-0.5 is a highly methyl-esterified homogalacturonan branched at O-3, probably by type II arabinogalactans and arabinans. In this study we showed that these balsam polysaccharides stimulate secretion of the cytokines TNF-α, IL-1β and IL-10 by THP-1 macrophages, acting as immunostimulatory agents. But, on the other hand, they reduce TNF-α and IL1-β secretion induced by a pro-inflammatory agent (LPS), showing anti-inflammatory effect.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0141-8130
1879-0003
1879-0003
DOI:10.1016/j.ijbiomac.2017.07.122