What determines the optimal pharmacological treatment of atrial fibrillation? Insights from in silico trials in 800 virtual atria

The best pharmacological treatment for each atrial fibrillation (AF) patient is unclear. We aim to exploit AF simulations in 800 virtual atria to identify key patient characteristics that guide the optimal selection of anti-arrhythmic drugs. The virtual cohort considered variability in electrophysio...

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Bibliographic Details
Published in:	The Journal of physiology Vol. 601; no. 18; pp. 4013 - 4032
Main Authors:	Dasí, Albert, Pope, Michael T.B., Wijesurendra, Rohan S., Betts, Tim R., Sachetto, Rafael, Bueno‐Orovio, Alfonso, Rodriguez, Blanca
Format:	Journal Article
Language:	English
Published:	England Wiley Subscription Services, Inc 01.09.2023 John Wiley and Sons Inc
Subjects:	Action Potentials - physiology Amiodarone Amiodarone - pharmacology Amiodarone - therapeutic use Atrial Fibrillation - drug therapy Atrium Calcium currents Cardiac arrhythmia Cardiovascular Clinical trials Drug therapy Electrophysiology Fibrillation Flecainide - pharmacology Flecainide - therapeutic use Heart Atria Humans Na+/K+-exchanging ATPase Patients Phenotyping Voltage atrial fibrillation ionic currents low voltage areas in silico drug trials
ISSN:	0022-3751, 1469-7793, 1469-7793
Online Access:	Get full text
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