Influence of red wine polysaccharides on cytochrome P450 enzymes and inflammatory parameters in tumor models

The soluble fraction of polysaccharides from cabernet franc red wine (SFP) previously showed antitumoral effects by modulating the immune system. The present study tested the hypothesis that the SFP can regulate CYPs in vitro in HepG2 cells and in vivo in Walker-256 tumor-bearing rats. The SFP was u...

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Bibliographic Details
Published in:	International journal of biological macromolecules Vol. 240; p. 124385
Main Authors:	Stipp, Maria Carolina, Kulik, Juliana Danna, Corso, Claudia Rita, Galindo, Claudia Martins, Adami, Eliana Rezende, Evangelista, Alberto Gonçalves, Luciano, Fernando Bittencourt, Winnischofer, Sheila Maria Brochado, Cadena, Silvia Maria Suter Correia, Sassaki, Guilherme Lanzi, Acco, Alexandra
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 15.06.2023
Subjects:	Acetylglucosaminidase Animals cancer chemoprevention cytochrome P-450 Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 digestion gene expression immune system Inflammation intestines liquids liver myeloperoxidase neoplasms nuclear magnetic resonance spectroscopy polysaccharides Polysaccharides - pharmacology Rats red wines vincristine Wine INF ALT MTT MPO DMEM ANOVA FBS qPCR CYP TLR SFP D2O PBS AST IL-1 Cytochrome P450 s.c i.p Inflammation EDTA IL-6 rpm PAMP NMR TNF-α NAG Veh SEM Vin cancer GAPDH VS ELISA
ISSN:	0141-8130, 1879-0003, 1879-0003
Online Access:	Get full text
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