Exposure to metals during pregnancy and neuropsychological development at the age of 4 years

There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (coba...

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Published in:Neurotoxicology (Park Forest South) Vol. 40; pp. 16 - 22
Main Authors: Forns, Joan, Fort, Marta, Casas, Maribel, Cáceres, Alejandro, Guxens, Mònica, Gascon, Mireia, Garcia-Esteban, Raquel, Julvez, Jordi, Grimalt, Joan O., Sunyer, Jordi
Format: Journal Article
Language:English
Published: Amsterdam Elsevier 01.01.2014
Subjects:
Air. Soil. Water. Waste. Feeding
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Child Development - drug effects
Child, Preschool
Environment. Living conditions
Female
General aspects
Humans
Male
Medical sciences
Metals - toxicity
Metals - urine
Metals and various inorganic compounds
Miscellaneous
Neuropsychological Tests
Pregnancy
Prenatal Exposure Delayed Effects - chemically induced
Public health. Hygiene
Public health. Hygiene-occupational medicine
Toxicology
Human
Environmental exposure
Toxicity
Nervous system
Cognition
Exposure
Heavy metals
Heavy metal
Pregnancy
Progeny
Health and environment
Child development
Environment
Female
Cognitive development
Neuropsychology
Woman
Child
Neuropsychologia
Public health
ADHD
HI
SCL-90-R
Q-ICP-MS
Revised Symptom Checklist
limits of detection
Coef
Weschler Adult Intelligence-Third Edition
environment and childhood project
IA
INMA
95% CI
LOD
MSCA
attention deficit and hyperactivity disorder
WAIS-III
McCarthy Scales of Children's Abilities
inductively coupled plasma quadruple mass spectrometry
hyperactivity/impulsivity scale
ADHD-DSM-IV
95% confidence interval
coefficient
ADHD Criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition form
inattention scale
ISSN:0161-813X, 1872-9711, 1872-9711
Online Access:Get full text
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Summary:There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age. This study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study. We found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years. Our results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years.
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ISSN:0161-813X
1872-9711
1872-9711
DOI:10.1016/j.neuro.2013.10.006