Effect of Synbiotic Supplementation in a Very‐Low‐Calorie Ketogenic Diet on Weight Loss Achievement and Gut Microbiota: A Randomized Controlled Pilot Study

Scope Little is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or the effect of synbiotics during the diet. The aim of this study is to evaluate changes in gut microbiota produced by a VLCKD and synbiotic supplementation. Methods and results A rando...

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Published in:Molecular nutrition & food research Vol. 63; no. 19; pp. e1900167 - n/a
Main Authors: Gutiérrez‐Repiso, Carolina, Hernández‐García, Carmen, García‐Almeida, José Manuel, Bellido, Diego, Martín‐Núñez, Gracia María, Sánchez‐Alcoholado, Lidia, Alcaide‐Torres, Juan, Sajoux, Ignacio, Tinahones, Francisco J., Moreno‐Indias, Isabel
Format: Journal Article
Language:English
Published: Germany Wiley Subscription Services, Inc 01.10.2019
Subjects:
bacteria
Bifidobacterium animalis subsp. lactis
Body weight loss
C-reactive protein
Diet
Dietary supplements
glucose
Gut microbiota
High fat diet
Hypocaloric diet
Inflammation
Intestinal microflora
intestinal microorganisms
Ketogenesis
ketogenic diet
Lachnospira
Lipopolysaccharides
low calorie diet
Low carbohydrate diet
Microbiota
Microorganisms
Nutrient deficiency
patients
placebos
PNK method
Prebiotics
Proteins
Randomization
synbiotic supplementation
very‐low‐calorie ketogenic diet
Weight loss
weight loss
very-low-calorie ketogenic diet
inflammation
PNK method
gut microbiota
synbiotic supplementation
ISSN:1613-4125, 1613-4133, 1613-4133
Online Access:Get full text
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Summary:Scope Little is known about the changes that a very‐low‐calorie ketogenic diet (VLCKD) produces in gut microbiota or the effect of synbiotics during the diet. The aim of this study is to evaluate changes in gut microbiota produced by a VLCKD and synbiotic supplementation. Methods and results A randomized, single‐blind, parallel‐design trial is conducted in 33 obese patients who follow a weight‐loss program (PnK‐Method) that include a VLCKD followed by a low‐calorie diet (LCD). Subjects are randomly allocated to three groups: one supplemented with synbiotics, a second group supplemented with a placebo during the VLCKD and synbiotics during the LCD phase, and a control group given a placebo. Although symbiotic administration do not produce an effect on microbial diversity, an increase in short‐chain fatty aciding producing bacteria and anti‐inflammatory mediator signals such as Odoribacter and Lachnospira is shown. The administration of Bifidobacterium animalis subsp. lactis and prebiotics fiber during the LCD is significantly associated with the percentage of weight loss and change in glucose, C‐reactive protein and lipopolysaccharide‐binding protein. Conclusions VLCKD produces important changes in gut microbiota. The administration of synbiotics during VLCKD can improve weight loss through the amelioration of inflammation, which may be mediated by the gut microbiota. Gut microbiota changes produced by a very‐low‐calorie ketogenic diet in obese patients are shown. Although the administration of synbiotics during the intervention does not have an effect on microbial diversity, they can contribute to the weight loss through the amelioration of the inflammation. The inflammation improvement can be mediated through the gut microbiota.
Bibliography:Clinical Trial Registry
This trial was registered at
www.clinicaltrials.gov
as NCT03530501.
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ISSN:1613-4125
1613-4133
1613-4133
DOI:10.1002/mnfr.201900167