Mineralisation of Developmentally Hypomineralised Human Enamel in vitro

Molar-incisor hypomineralisation (MIH) is a problematic and costly condition. Caries remineralising agents are often recommended for MIH management despite the lack of evidence that these lesions have the capacity for increasing their mineral content. Following surface layer removal ± NaOCl pre-trea...

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Bibliographic Details
Published in:Caries research Vol. 47; no. 3; pp. 259 - 263
Main Authors: Crombie, F.A., Cochrane, N.J., Manton, D.J., Palamara, J.E.A., Reynolds, E.C.
Format: Journal Article
Language:English
Published: Basel, Switzerland S. Karger AG 01.01.2013
Subjects:
Caseins - therapeutic use
Dental Enamel Hypoplasia - therapy
Humans
In Vitro Techniques
Incisor - chemistry
Incisor - pathology
Microradiography
Molar - chemistry
Molar - pathology
Short Communication
Tooth Remineralization - methods
Mineralisation
Casein phosphopeptide amorphous calcium fluoride phosphate
Developmental enamel defects
Molar-incisor hypomineralisation
ISSN:0008-6568, 1421-976X, 1421-976X
Online Access:Get full text
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Summary:Molar-incisor hypomineralisation (MIH) is a problematic and costly condition. Caries remineralising agents are often recommended for MIH management despite the lack of evidence that these lesions have the capacity for increasing their mineral content. Following surface layer removal ± NaOCl pre-treatment and 14-day exposure to a CPP-ACFP solution at pH 5.5, MIH lesions were analysed using transverse microradiography and polarised light microscopy. Lesions were highly variable but treatment with the remineralising solution increased mineral content (1,828 ± 461 vol% min·µm, %R = 17.7 ± 5.7) and porosity decreased demonstrating the proof of concept that the mineral content of developmentally hypomineralised enamel can be improved after eruption.
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ISSN:0008-6568
1421-976X
1421-976X
DOI:10.1159/000346134