Recent advances in cellular optogenetics for photomedicine

[Display omitted] Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be prec...

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Published in:Advanced drug delivery reviews Vol. 188; p. 114457
Main Authors: Chen, Bing, Cui, Meihui, Wang, Yuan, Shi, Peng, Wang, Hanjie, Wang, Feng
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.09.2022
Subjects:
Animals
Brain - physiology
Channelrhodopsins - metabolism
Humans
Light delivery
Mammals - physiology
Microbiota - physiology
Neuronal regulation
Neurons - metabolism
Optogenetic tools
Optogenetics - methods
Optogenetics - trends
Phototherapy
Phototherapy - trends
Signal Transduction
Signaling pathways
Signaling pathways
Neuronal regulation
Optogenetic tools
Light delivery
Phototherapy
ISSN:0169-409X, 1872-8294, 1872-8294
Online Access:Get full text
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Summary:[Display omitted] Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2022.114457