Investigation of keratolytic impact of synthetic bolalipids on skin penetration of a model hydrophilic permeant

[Display omitted] •Single-chain bolalipids PC-C24-PC and PC-C32-PC do not enhance skin penetration of a hydrophilic permeant from aqueous vehicles into porcine ear skin.•Single-chain bolalipids strongly reduce corneocyte cohesion during ex vivo tape stripping.•The effect on corneocyte cohesion resem...

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Vydané v:	European journal of pharmaceutics and biopharmaceutics Ročník 203; s. 114433
Hlavní autori:	Abdelrahman, Namarig, Drescher, Simon, Ann Dailey, Lea, Klang, Victoria
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Netherlands Elsevier B.V 01.10.2024
Predmet:	Administration, Cutaneous Animals Bolalipids Chemistry, Pharmaceutical - methods Drug Delivery Systems - methods Excipients - chemistry Fluorescein Hydrophobic and Hydrophilic Interactions Keratolytic Permeability Skin - drug effects Skin - metabolism Skin Absorption - drug effects Skin barrier Skin penetration Sodium fluorescein Surfactants Swine Tape stripping Viscosity Skin penetration PEG‐HS SDS CAC PC‐75 Tape stripping DLS Surfactants HET-CAM Sodium fluorescein SC Keratolytic PC SF Skin barrier PDI Bolalipids SSCB Tm TEL
ISSN:	0939-6411, 1873-3441, 1873-3441
On-line prístup:	Získať plný text
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