Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,1...

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Vydané v:	Cell host & microbe Ročník 20; číslo 6; s. 810
Hlavní autori:	Bi, Yuhai, Chen, Quanjiao, Wang, Qianli, Chen, Jianjun, Jin, Tao, Wong, Gary, Quan, Chuansong, Liu, Jun, Wu, Jun, Yin, Renfu, Zhao, Lihua, Li, Mingxin, Ding, Zhuang, Zou, Rongrong, Xu, Wen, Li, Hong, Wang, Huijun, Tian, Kegong, Fu, Guanghua, Huang, Yu, Shestopalov, Alexander, Li, Shoujun, Xu, Bing, Yu, Hongjie, Luo, Tingrong, Lu, Lin, Xu, Xun, Luo, Yang, Liu, Yingxia, Shi, Weifeng, Liu, Di, Gao, George Fu
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 14.12.2016
Predmet:	Agriculture Animals Base Sequence Chickens - virology China - epidemiology Cities Columbidae - virology Ducks - virology Epidemiological Monitoring Evolution, Molecular Geese - virology Genes, Viral - genetics Genome, Viral Genotype Geographic Mapping Hemagglutinins Humans Influenza A Virus, H5N1 Subtype - genetics Influenza A Virus, H5N1 Subtype - pathogenicity Influenza A Virus, H5N8 Subtype - classification Influenza A Virus, H5N8 Subtype - genetics Influenza A Virus, H5N8 Subtype - isolation & purification Influenza A Virus, H5N8 Subtype - pathogenicity Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - pathogenicity Influenza A Virus, H9N2 Subtype - genetics Influenza A Virus, H9N2 Subtype - pathogenicity Influenza in Birds - epidemiology Influenza in Birds - virology Influenza, Human - epidemiology Influenza, Human - virology Neuraminidase Phylogeny Poultry - virology Prevalence Public Health Reassortant Viruses RNA, Viral - genetics genesis prevalence live poultry markets H5N6 avian influenza resassortment evolution birds human infection
ISSN:	1934-6069, 1934-6069
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Shrnutí:	Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1934-6069 1934-6069
DOI:	10.1016/j.chom.2016.10.022