Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,1...

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Veröffentlicht in:Cell host & microbe Jg. 20; H. 6; S. 810
Hauptverfasser: Bi, Yuhai, Chen, Quanjiao, Wang, Qianli, Chen, Jianjun, Jin, Tao, Wong, Gary, Quan, Chuansong, Liu, Jun, Wu, Jun, Yin, Renfu, Zhao, Lihua, Li, Mingxin, Ding, Zhuang, Zou, Rongrong, Xu, Wen, Li, Hong, Wang, Huijun, Tian, Kegong, Fu, Guanghua, Huang, Yu, Shestopalov, Alexander, Li, Shoujun, Xu, Bing, Yu, Hongjie, Luo, Tingrong, Lu, Lin, Xu, Xun, Luo, Yang, Liu, Yingxia, Shi, Weifeng, Liu, Di, Gao, George Fu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 14.12.2016
Schlagworte:
Agriculture
Animals
Base Sequence
Chickens - virology
China - epidemiology
Cities
Columbidae - virology
Ducks - virology
Epidemiological Monitoring
Evolution, Molecular
Geese - virology
Genes, Viral - genetics
Genome, Viral
Genotype
Geographic Mapping
Hemagglutinins
Humans
Influenza A Virus, H5N1 Subtype - genetics
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza A Virus, H5N8 Subtype - classification
Influenza A Virus, H5N8 Subtype - genetics
Influenza A Virus, H5N8 Subtype - isolation & purification
Influenza A Virus, H5N8 Subtype - pathogenicity
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - pathogenicity
Influenza A Virus, H9N2 Subtype - genetics
Influenza A Virus, H9N2 Subtype - pathogenicity
Influenza in Birds - epidemiology
Influenza in Birds - virology
Influenza, Human - epidemiology
Influenza, Human - virology
Neuraminidase
Phylogeny
Poultry - virology
Prevalence
Public Health
Reassortant Viruses
RNA, Viral - genetics
genesis
prevalence
live poultry markets
H5N6 avian influenza
resassortment
evolution
birds
human infection
ISSN:1934-6069, 1934-6069
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Zusammenfassung:Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2016.10.022