Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We perfor...

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Veröffentlicht in:Cell Jg. 187; H. 17; S. 4554
Hauptverfasser: Piperni, Elisa, Nguyen, Long H, Manghi, Paolo, Kim, Hanseul, Pasolli, Edoardo, Andreu-Sánchez, Sergio, Arrè, Alberto, Bermingham, Kate M, Blanco-Míguez, Aitor, Manara, Serena, Valles-Colomer, Mireia, Bakker, Elco, Busonero, Fabio, Davies, Richard, Fiorillo, Edoardo, Giordano, Francesca, Hadjigeorgiou, George, Leeming, Emily R, Lobina, Monia, Masala, Marco, Maschio, Andrea, McIver, Lauren J, Pala, Mauro, Pitzalis, Maristella, Wolf, Jonathan, Fu, Jingyuan, Zhernakova, Alexandra, Cacciò, Simone M, Cucca, Francesco, Berry, Sarah E, Ercolini, Danilo, Chan, Andrew T, Huttenhower, Curtis, Spector, Tim D, Segata, Nicola, Asnicar, Francesco
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 22.08.2024
Schlagworte:
Adult
Blastocystis - metabolism
Blastocystis Infections
Cardiovascular Diseases - prevention & control
Diet
Female
Gastrointestinal Microbiome
Humans
Intestines - microbiology
Intestines - parasitology
Male
Metagenome
Middle Aged
Obesity
diet and microbiome
integrative metagenomics
metagenomics
microbiome meta-analysis
transkingdom microbiome analysis
cardiometabolic health
micro-eukaryote
Blastocystis hominis
human gut microbiome
ISSN:1097-4172, 1097-4172
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Zusammenfassung:Diet impacts human health, influencing body adiposity and the risk of developing cardiometabolic diseases. The gut microbiome is a key player in the diet-health axis, but while its bacterial fraction is widely studied, the role of micro-eukaryotes, including Blastocystis, is underexplored. We performed a global-scale analysis on 56,989 metagenomes and showed that human Blastocystis exhibits distinct prevalence patterns linked to geography, lifestyle, and dietary habits. Blastocystis presence defined a specific bacterial signature and was positively associated with more favorable cardiometabolic profiles and negatively with obesity (p < 1e-16) and disorders linked to altered gut ecology (p < 1e-8). In a diet intervention study involving 1,124 individuals, improvements in dietary quality were linked to weight loss and increases in Blastocystis prevalence (p = 0.003) and abundance (p < 1e-7). Our findings suggest a potentially beneficial role for Blastocystis, which may help explain personalized host responses to diet and downstream disease etiopathogenesis.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1097-4172
1097-4172
DOI:10.1016/j.cell.2024.06.018