Transcriptional landscapes underlying Notch-induced lineage conversion and plasticity of mammary basal cells

The mammary epithelium derives from multipotent mammary stem cells (MaSCs) that engage into differentiation during embryonic development. However, adult MaSCs maintain the ability to reactivate multipotency in non-physiological contexts. We previously reported that Notch1 activation in committed bas...

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Vydáno v:	The EMBO journal Ročník 44; číslo 10; s. 2827 - 2855
Hlavní autoři:	Merle, Candice, Rodrigues, Calvin, Pourkhalili Langeroudi, Atefeh, Journot, Robin, Rost, Fabian, Dang, Yiteng, Rulands, Steffen, Fre, Silvia
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 16.05.2025
Témata:	Animals Biomedical and Life Sciences Cell Differentiation Cell Lineage Cell Plasticity Cell Proliferation EMBO09 EMBO11 EMBO34 Epithelial Cells - cytology Epithelial Cells - metabolism Female Life Sciences Mammary Glands, Animal - cytology Mammary Glands, Animal - metabolism Mice Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Signal Transduction Single-Cell Analysis Transcriptome Lineage Conversion Notch1 Signaling Epithelial Stem Cells Plasticity
ISSN:	1460-2075, 0261-4189, 1460-2075
On-line přístup:	Získat plný text
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