Cholesteryl esters: fueling the fury of prostate cancer

Tumors display distinct metabolic programs, and altered lipid metabolism is emerging as an important process in cancer. In this issue, Yue et al. (2014) report that aberrant cholesteryl ester accumulation is found in advanced prostate cancers with PTEN loss and PI3K/AKT activation. Importantly, inhi...

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Bibliographic Details
Published in:	Cell metabolism Vol. 19; no. 3; p. 350
Main Authors:	Peck, Barrie, Schulze, Almut
Format:	Journal Article
Language:	English
Published:	United States 04.03.2014
Subjects:	Animals Cholesterol Esters - metabolism Humans Male Phosphatidylinositol 3-Kinase - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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Summary:	Tumors display distinct metabolic programs, and altered lipid metabolism is emerging as an important process in cancer. In this issue, Yue et al. (2014) report that aberrant cholesteryl ester accumulation is found in advanced prostate cancers with PTEN loss and PI3K/AKT activation. Importantly, inhibition of cholesterol esterification impaired cancer aggressiveness.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23
ISSN:	1932-7420 1932-7420
DOI:	10.1016/j.cmet.2014.02.012