Cholesteryl esters: fueling the fury of prostate cancer

Tumors display distinct metabolic programs, and altered lipid metabolism is emerging as an important process in cancer. In this issue, Yue et al. (2014) report that aberrant cholesteryl ester accumulation is found in advanced prostate cancers with PTEN loss and PI3K/AKT activation. Importantly, inhi...

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Vydáno v:Cell metabolism Ročník 19; číslo 3; s. 350
Hlavní autoři: Peck, Barrie, Schulze, Almut
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 04.03.2014
Témata:
Animals
Cholesterol Esters - metabolism
Humans
Male
Phosphatidylinositol 3-Kinase - metabolism
Proto-Oncogene Proteins c-akt - metabolism
PTEN Phosphohydrolase - metabolism
ISSN:1932-7420, 1932-7420
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Shrnutí:Tumors display distinct metabolic programs, and altered lipid metabolism is emerging as an important process in cancer. In this issue, Yue et al. (2014) report that aberrant cholesteryl ester accumulation is found in advanced prostate cancers with PTEN loss and PI3K/AKT activation. Importantly, inhibition of cholesterol esterification impaired cancer aggressiveness.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
content type line 23
ISSN:1932-7420
1932-7420
DOI:10.1016/j.cmet.2014.02.012