Low-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT

Irritable bowel syndrome, characterised by abdominal pain and a change in stool form or frequency, is most often managed in primary care. When first-line therapies are ineffective, National Institute for Health and Care Excellence guidelines suggest considering low-dose tricyclic antidepressants as...

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Bibliographic Details
Published in:	Health technology assessment (Winchester, England) Vol. 28; no. 66; pp. 1 - 161
Main Authors:	Wright-Hughes, Alexandra, Ford, Alexander C, Alderson, Sarah L, Ow, Pei Loo, Ridd, Matthew J, Foy, Robbie, Bishop, Felicity L, Chaddock, Matthew, Cook, Heather, Cooper, Deborah, Fernandez, Catherine, Guthrie, Elspeth A, Hartley, Suzanne, Herbert, Amy, Howdon, Daniel, Muir, Delia P, Newman, Sonia, Taylor, Christopher A, Teasdale, Emma J, Thornton, Ruth, Everitt, Hazel A, Farrin, Amanda J
Format:	Journal Article
Language:	English
Published:	England NIHR Journals Library 01.10.2024
Subjects:	abdominal pain Adult amitriptyline Amitriptyline - administration & dosage Amitriptyline - therapeutic use Antidepressive Agents, Tricyclic - administration & dosage Antidepressive Agents, Tricyclic - therapeutic use Cost-Benefit Analysis Double-Blind Method England Female general practice Humans irritable bowel syndrome Irritable Bowel Syndrome - drug therapy Male Middle Aged outcome assessment Primary Health Care Quality of Life Quality-Adjusted Life Years randomised controlled trial England AMITRIPTYLINE ABDOMINAL PAIN OUTCOME ASSESSMENT GENERAL PRACTICE RANDOMISED CONTROLLED TRIAL IRRITABLE BOWEL SYNDROME
ISSN:	2046-4924, 1366-5278, 2046-4924
Online Access:	Get full text
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