Evaluating the role of ENOSF1 and TYMS variants as predictors in fluoropyrimidine-related toxicities: An IPD meta-analysis

[Display omitted] To assess the proposed associations of the c.742-227G>A (rs2612091) polymorphism within the Enolase Superfamily Member 1 gene (ENOSF1) and two variants in the adjacent Thymidylate Synthase gene (TYMS): the 5’VNTR 28bp-repeat (rs45445694) and 3’UTR 6bp-indel (rs11280056) with sev...

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Bibliographic Details
Published in:	Pharmacological research Vol. 152; p. 104594
Main Authors:	Hamzic, Seid, Kummer, Dominic, Froehlich, Tanja K., Joerger, Markus, Aebi, Stefan, Palles, Claire, Thomlinson, Ian, Meulendijks, Didier, Schellens, Jan H.M., García-González, Xandra, López-Fernández, Luis A., Amstutz, Ursula, Largiadèr, Carlo R.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.02.2020
Subjects:	Antimetabolites, Antineoplastic - adverse effects Capecitabine Capecitabine - adverse effects ENOSF1 Fluorouracil Fluorouracil - adverse effects Hand-Foot Syndrome - genetics Hand-foot-syndrome Humans Hydro-Lyases - genetics Neoplasms - drug therapy Neoplasms - genetics Thymidylate Synthase - genetics TYMS TYMS Capecitabine ENOSF1 Hand-foot-syndrome Fluorouracil
ISSN:	1043-6618, 1096-1186, 1096-1186
Online Access:	Get full text
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