Soluble programmed death-ligand 1 (sPDL1) and neutrophil-to-lymphocyte ratio (NLR) predicts survival in advanced biliary tract cancer patients treated with palliative chemotherapy

Programmed death-ligand 1 (PD-L1) expression in tumor tissue is under investigation as a candidate biomarker in immuno-oncology dug development. The soluble form of PD-L1 (sPDL1) is suggested to have immunosuppressive activity. In this study, we measured the serum level of sPDL1 and evaluated its pr...

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Vydáno v:Oncotarget Ročník 7; číslo 47; s. 76604 - 76612
Hlavní autoři: Ha, Hyerim, Nam, Ah-Rong, Bang, Ju-Hee, Park, Ji-Eun, Kim, Tae-Yong, Lee, Kyung-Hun, Han, Sae-Won, Im, Seock-Ah, Kim, Tae-You, Bang, Yung-Jue, Oh, Do-Youn
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 22.11.2016
Témata:
Adult
Aged
B7-H1 Antigen - blood
Bile Duct Neoplasms - blood
Bile Duct Neoplasms - diagnosis
Bile Duct Neoplasms - drug therapy
Bile Duct Neoplasms - mortality
Biomarkers
Chemotherapy, Adjuvant
Female
Humans
Leukocyte Count
Lymphocytes
Male
Middle Aged
Neoplasm Staging
Neutrophils
Palliative Care
Prognosis
Treatment Outcome
biliary tract cancer
PDL1
biomarker
soluble PDL1
immunotherapy
ISSN:1949-2553
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Shrnutí:Programmed death-ligand 1 (PD-L1) expression in tumor tissue is under investigation as a candidate biomarker in immuno-oncology dug development. The soluble form of PD-L1 (sPDL1) is suggested to have immunosuppressive activity. In this study, we measured the serum level of sPDL1 and evaluated its prognostic implication in biliary tract cancer (BTC). Blood was collected from 158 advanced BTC patients (68 intrahepatic cholangiocarcinoma, 56 gallbladder cancer, 22 extrahepatic cholangiocarcinoma and 12 ampulla of vater cancer) before initiation of palliative chemotherapy. Serum sPDL1 was measured using an enzyme-linked immunosorbent assay. Clinical data included neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII, neutrophil × platelet/lymphocyte). The patients were assigned to two cohorts (training and validation cohort) using a simple random sampling method to validate the cut-off value of each marker. Validation was performed using a twofold cross-validation method. Overall survival (OS) of all patients was 9.07 months (95% CI: 8.20-11.33). Median sPDL1 was 1.20 ng/mL (range 0.03-7.28, mean 1.50, SD 1.22). Median NLR, PLR and SII were 2.60, 142.85 and 584.93, respectively. Patients with high sPDL1 (≥0.94 ng/mL) showed worse OS than patients with low sPDL1 (7.93 vs. 14.10 months, HR 1.891 (1.35-2.65), p<0.001). In multivariate analysis, high sPDL1 and NLR were independent poor prognostic factors. In conclusion, serum sPDL1 can be measured and has significant role on the prognosis of advanced BTC patients treated with palliative chemotherapy.
Bibliografie:ObjectType-Article-1
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content type line 23
ISSN:1949-2553
DOI:10.18632/oncotarget.12810