Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems

In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the ‘IntegNeuro’ computerized battery of neurops...

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Bibliographic Details
Published in:	Biological psychology Vol. 80; no. 2; pp. 176 - 188
Main Authors:	Schofield, Peter R., Williams, Leanne M., Paul, Robert H., Gatt, Justine M., Brown, Kerri, Luty, Agnes, Cooper, Nicholas, Grieve, Stuart, Dobson-Stone, Carol, Morris, Charlotte, Kuan, Stacey A., Gordon, Evian
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 01.02.2009 Elsevier
Subjects:	Acoustic Stimulation - methods Adult Analysis of Variance Automatic Data Processing - methods BDNF Val66Met Behavioral psychophysiology Biological and medical sciences Brain derived neurotrophic factor Brain Mapping Brain-Derived Neurotrophic Factor - genetics Chi-Square Distribution Cognition Cognition - physiology Cohort Studies Event-Related Potentials, P300 - genetics Female Frontal Lobe - blood supply Frontal Lobe - physiology Fundamental and applied biological sciences. Psychology Genotype Grey matter Hippocampus Hippocampus - blood supply Hippocampus - physiology Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Methionine - genetics Middle Aged Neural Pathways - blood supply Neural Pathways - physiology Neuroimaging Neuropsychological Tests Oxygen - blood P300 event-related potential Polymorphism, Genetic - genetics Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Regression Analysis Valine - genetics Young Adult Neuroimaging Grey matter BDNF Val66Met Cognition Brain derived neurotrophic factor P300 event-related potential Hippocampus Central nervous system Electrophysiology P300 potential Encephalon Information processing Event evoked potential Polymorphism
ISSN:	0301-0511, 1873-6246, 1873-6246
Online Access:	Get full text
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