Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems

In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the ‘IntegNeuro’ computerized battery of neurops...

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Published in:Biological psychology Vol. 80; no. 2; pp. 176 - 188
Main Authors: Schofield, Peter R., Williams, Leanne M., Paul, Robert H., Gatt, Justine M., Brown, Kerri, Luty, Agnes, Cooper, Nicholas, Grieve, Stuart, Dobson-Stone, Carol, Morris, Charlotte, Kuan, Stacey A., Gordon, Evian
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 01.02.2009
Elsevier
Subjects:
Acoustic Stimulation - methods
Adult
Analysis of Variance
Automatic Data Processing - methods
BDNF Val66Met
Behavioral psychophysiology
Biological and medical sciences
Brain derived neurotrophic factor
Brain Mapping
Brain-Derived Neurotrophic Factor - genetics
Chi-Square Distribution
Cognition
Cognition - physiology
Cohort Studies
Event-Related Potentials, P300 - genetics
Female
Frontal Lobe - blood supply
Frontal Lobe - physiology
Fundamental and applied biological sciences. Psychology
Genotype
Grey matter
Hippocampus
Hippocampus - blood supply
Hippocampus - physiology
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Methionine - genetics
Middle Aged
Neural Pathways - blood supply
Neural Pathways - physiology
Neuroimaging
Neuropsychological Tests
Oxygen - blood
P300 event-related potential
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Regression Analysis
Valine - genetics
Young Adult
Neuroimaging
Grey matter
BDNF Val66Met
Cognition
Brain derived neurotrophic factor
P300 event-related potential
Hippocampus
Central nervous system
Electrophysiology
P300 potential
Encephalon
Information processing
Event evoked potential
Polymorphism
ISSN:0301-0511, 1873-6246, 1873-6246
Online Access:Get full text
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Summary:In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the ‘IntegNeuro’ computerized battery of neuropsychological tests to assess cognitive performance, an auditory oddball task to elicit the P300 event-related potential (ERP) and, in smaller subsets of these subjects, high resolution structural MRI imaging to quantify fronto-hippocampal grey matter ( n = 161), and functional magnetic resonance imaging to assess fronto-hippocampal BOLD activation ( n = 37). Met/Met (MM) homozygotes had higher verbal recall errors, in the absence of differences in attention, executive function, verbal ability or sensori-motor function. Further, MM homozygotes demonstrated a slowed P300 ERP during the oddball task, with corresponding alterations in hippocampal and lateral prefrontal activation, and a localized reduction in hippocampal grey matter. These results are consistent with a subtle impact of the Met allele on fronto-hippocampal systems involved in selective information processing of stimulus context and memory updating within the normal population. The findings also indicate that heritable endophenotypes such as the P300 have value in elucidating genotype–phenotype relationships.
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ISSN:0301-0511
1873-6246
1873-6246
DOI:10.1016/j.biopsycho.2008.09.001