Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems

In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the ‘IntegNeuro’ computerized battery of neurops...

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Veröffentlicht in:Biological psychology Jg. 80; H. 2; S. 176 - 188
Hauptverfasser: Schofield, Peter R., Williams, Leanne M., Paul, Robert H., Gatt, Justine M., Brown, Kerri, Luty, Agnes, Cooper, Nicholas, Grieve, Stuart, Dobson-Stone, Carol, Morris, Charlotte, Kuan, Stacey A., Gordon, Evian
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Amsterdam Elsevier B.V 01.02.2009
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ISSN:0301-0511, 1873-6246, 1873-6246
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Abstract In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the ‘IntegNeuro’ computerized battery of neuropsychological tests to assess cognitive performance, an auditory oddball task to elicit the P300 event-related potential (ERP) and, in smaller subsets of these subjects, high resolution structural MRI imaging to quantify fronto-hippocampal grey matter ( n = 161), and functional magnetic resonance imaging to assess fronto-hippocampal BOLD activation ( n = 37). Met/Met (MM) homozygotes had higher verbal recall errors, in the absence of differences in attention, executive function, verbal ability or sensori-motor function. Further, MM homozygotes demonstrated a slowed P300 ERP during the oddball task, with corresponding alterations in hippocampal and lateral prefrontal activation, and a localized reduction in hippocampal grey matter. These results are consistent with a subtle impact of the Met allele on fronto-hippocampal systems involved in selective information processing of stimulus context and memory updating within the normal population. The findings also indicate that heritable endophenotypes such as the P300 have value in elucidating genotype–phenotype relationships.
AbstractList In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the ‘IntegNeuro’ computerized battery of neuropsychological tests to assess cognitive performance, an auditory oddball task to elicit the P300 event-related potential (ERP) and, in smaller subsets of these subjects, high resolution structural MRI imaging to quantify fronto-hippocampal grey matter ( n = 161), and functional magnetic resonance imaging to assess fronto-hippocampal BOLD activation ( n = 37). Met/Met (MM) homozygotes had higher verbal recall errors, in the absence of differences in attention, executive function, verbal ability or sensori-motor function. Further, MM homozygotes demonstrated a slowed P300 ERP during the oddball task, with corresponding alterations in hippocampal and lateral prefrontal activation, and a localized reduction in hippocampal grey matter. These results are consistent with a subtle impact of the Met allele on fronto-hippocampal systems involved in selective information processing of stimulus context and memory updating within the normal population. The findings also indicate that heritable endophenotypes such as the P300 have value in elucidating genotype–phenotype relationships.
In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the 'IntegNeuro' computerized battery of neuropsychological tests to assess cognitive performance, an auditory oddball task to elicit the P300 event-related potential (ERP) and, in smaller subsets of these subjects, high resolution structural MRI imaging to quantify fronto-hippocampal grey matter (n=161), and functional magnetic resonance imaging to assess fronto-hippocampal BOLD activation (n=37). Met/Met (MM) homozygotes had higher verbal recall errors, in the absence of differences in attention, executive function, verbal ability or sensori-motor function. Further, MM homozygotes demonstrated a slowed P300 ERP during the oddball task, with corresponding alterations in hippocampal and lateral prefrontal activation, and a localized reduction in hippocampal grey matter. These results are consistent with a subtle impact of the Met allele on fronto-hippocampal systems involved in selective information processing of stimulus context and memory updating within the normal population. The findings also indicate that heritable endophenotypes such as the P300 have value in elucidating genotype-phenotype relationships.
In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the 'IntegNeuro' computerized battery of neuropsychological tests to assess cognitive performance, an auditory oddball task to elicit the P300 event-related potential (ERP) and, in smaller subsets of these subjects, high resolution structural MRI imaging to quantify fronto-hippocampal grey matter (n=161), and functional magnetic resonance imaging to assess fronto-hippocampal BOLD activation (n=37). Met/Met (MM) homozygotes had higher verbal recall errors, in the absence of differences in attention, executive function, verbal ability or sensori-motor function. Further, MM homozygotes demonstrated a slowed P300 ERP during the oddball task, with corresponding alterations in hippocampal and lateral prefrontal activation, and a localized reduction in hippocampal grey matter. These results are consistent with a subtle impact of the Met allele on fronto-hippocampal systems involved in selective information processing of stimulus context and memory updating within the normal population. The findings also indicate that heritable endophenotypes such as the P300 have value in elucidating genotype-phenotype relationships.In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information processing. In 475 non-clinical participants for whom BDNF genotype status was determined we used the 'IntegNeuro' computerized battery of neuropsychological tests to assess cognitive performance, an auditory oddball task to elicit the P300 event-related potential (ERP) and, in smaller subsets of these subjects, high resolution structural MRI imaging to quantify fronto-hippocampal grey matter (n=161), and functional magnetic resonance imaging to assess fronto-hippocampal BOLD activation (n=37). Met/Met (MM) homozygotes had higher verbal recall errors, in the absence of differences in attention, executive function, verbal ability or sensori-motor function. Further, MM homozygotes demonstrated a slowed P300 ERP during the oddball task, with corresponding alterations in hippocampal and lateral prefrontal activation, and a localized reduction in hippocampal grey matter. These results are consistent with a subtle impact of the Met allele on fronto-hippocampal systems involved in selective information processing of stimulus context and memory updating within the normal population. The findings also indicate that heritable endophenotypes such as the P300 have value in elucidating genotype-phenotype relationships.
Author Williams, Leanne M.
Gatt, Justine M.
Cooper, Nicholas
Luty, Agnes
Paul, Robert H.
Dobson-Stone, Carol
Schofield, Peter R.
Grieve, Stuart
Morris, Charlotte
Gordon, Evian
Kuan, Stacey A.
Brown, Kerri
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  surname: Williams
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  email: lea_williams@wmi.usyd.edu.au
  organization: Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School (Psychological Medicine), University of Sydney, Westmead Hospital, Westmead, Sydney 2145, Australia
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  surname: Paul
  fullname: Paul, Robert H.
  organization: Behavioral Neuroscience Program, Department of Psychology, University of Missouri-St. Louis, 412 Stadler Hall & 08 Weinman Bldg, One University Boulevard, St. Louis, MO 63121-4499, United States
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  surname: Gatt
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  organization: Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School (Psychological Medicine), University of Sydney, Westmead Hospital, Westmead, Sydney 2145, Australia
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  surname: Brown
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  organization: Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School (Psychological Medicine), University of Sydney, Westmead Hospital, Westmead, Sydney 2145, Australia
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  givenname: Agnes
  surname: Luty
  fullname: Luty, Agnes
  organization: Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, Sydney 2010, Australia
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  surname: Cooper
  fullname: Cooper, Nicholas
  organization: Brain Resource International Database, Brain Resource Company, 237 Jones St, Ultimo, Sydney 2007, Australia
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  surname: Grieve
  fullname: Grieve, Stuart
  organization: Brain Resource International Database, Brain Resource Company, 237 Jones St, Ultimo, Sydney 2007, Australia
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  givenname: Carol
  surname: Dobson-Stone
  fullname: Dobson-Stone, Carol
  organization: Prince of Wales Medical Research Institute, Barker Street, Randwick, Sydney 2031, Australia
– sequence: 10
  givenname: Charlotte
  surname: Morris
  fullname: Morris, Charlotte
  organization: Brain Resource International Database, Brain Resource Company, 237 Jones St, Ultimo, Sydney 2007, Australia
– sequence: 11
  givenname: Stacey A.
  surname: Kuan
  fullname: Kuan, Stacey A.
  organization: Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School (Psychological Medicine), University of Sydney, Westmead Hospital, Westmead, Sydney 2145, Australia
– sequence: 12
  givenname: Evian
  surname: Gordon
  fullname: Gordon, Evian
  organization: Brain Dynamics Centre, Westmead Millennium Institute and Western Clinical School (Psychological Medicine), University of Sydney, Westmead Hospital, Westmead, Sydney 2145, Australia
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Issue 2
Keywords Neuroimaging
Grey matter
BDNF Val66Met
Cognition
Brain derived neurotrophic factor
P300 event-related potential
Hippocampus
Central nervous system
Electrophysiology
P300 potential
Encephalon
Information processing
Event evoked potential
Polymorphism
Language English
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crossref_citationtrail_10_1016_j_biopsycho_2008_09_001
crossref_primary_10_1016_j_biopsycho_2008_09_001
elsevier_sciencedirect_doi_10_1016_j_biopsycho_2008_09_001
PublicationCentury 2000
PublicationDate 2009-02-01
PublicationDateYYYYMMDD 2009-02-01
PublicationDate_xml – month: 02
  year: 2009
  text: 2009-02-01
  day: 01
PublicationDecade 2000
PublicationPlace Amsterdam
PublicationPlace_xml – name: Amsterdam
– name: Netherlands
PublicationTitle Biological psychology
PublicationTitleAlternate Biol Psychol
PublicationYear 2009
Publisher Elsevier B.V
Elsevier
Publisher_xml – name: Elsevier B.V
– name: Elsevier
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Snippet In this study, we examined whether the Met allele of the BDNF Val66Met polymorphism is associated with selective disruptions to task-relevant information...
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StartPage 176
SubjectTerms Acoustic Stimulation - methods
Adult
Analysis of Variance
Automatic Data Processing - methods
BDNF Val66Met
Behavioral psychophysiology
Biological and medical sciences
Brain derived neurotrophic factor
Brain Mapping
Brain-Derived Neurotrophic Factor - genetics
Chi-Square Distribution
Cognition
Cognition - physiology
Cohort Studies
Event-Related Potentials, P300 - genetics
Female
Frontal Lobe - blood supply
Frontal Lobe - physiology
Fundamental and applied biological sciences. Psychology
Genotype
Grey matter
Hippocampus
Hippocampus - blood supply
Hippocampus - physiology
Humans
Image Processing, Computer-Assisted - methods
Magnetic Resonance Imaging - methods
Male
Methionine - genetics
Middle Aged
Neural Pathways - blood supply
Neural Pathways - physiology
Neuroimaging
Neuropsychological Tests
Oxygen - blood
P300 event-related potential
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Regression Analysis
Valine - genetics
Young Adult
Title Disturbances in selective information processing associated with the BDNF Val66Met polymorphism: Evidence from cognition, the P300 and fronto-hippocampal systems
URI https://dx.doi.org/10.1016/j.biopsycho.2008.09.001
https://www.ncbi.nlm.nih.gov/pubmed/18838100
https://www.proquest.com/docview/66904245
Volume 80
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