An incidental B-lymphoblastic leukemia/lymphoma in a prophylactic salpingo-oophorectomy from a patient with germline BRCA1 mutation

B-lymphoblastic leukemia/lymphoma (B-ALL) is a malignant neoplasm of immature B lymphocytes. Occasionally, B-ALL may exhibit morphological and immunophenotypic overlaps with other hematologic malignancies such as B-ALL with isolated myeloperoxidase (MPO) expression which may complicate diagnosis. BR...

Full description

Saved in:
Bibliographic Details
Published in:Human Pathology Reports Vol. 42; p. 300795
Main Authors: Edema, Ukuemi, Chan, Alexander
Format: Journal Article
Language:English
Published: Elsevier Inc 01.11.2025
Subjects:
B-ALL
BRCA
Germline mutation
Leukemia
Pathology
Risk reduction
Risk reduction
B-ALL
BRCA
Germline mutation
Leukemia
ISSN:2772-736X, 2772-736X
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:B-lymphoblastic leukemia/lymphoma (B-ALL) is a malignant neoplasm of immature B lymphocytes. Occasionally, B-ALL may exhibit morphological and immunophenotypic overlaps with other hematologic malignancies such as B-ALL with isolated myeloperoxidase (MPO) expression which may complicate diagnosis. BRCA1 and BRCA2 are tumor suppressor genes involved in homologous recombination and DNA repair. While germline mutations in these genes are well-established risk factors for breast and ovarian cancers, the association between BRCA1/2 mutations and hematologic malignancies remains underexplored. We present a rare case of B-ALL with isolated MPO expression, discovered incidentally in prophylactically resected ovaries of a patient with a germline BRCA1 mutation, and review the literature exploring this potential association.
ISSN:2772-736X
2772-736X
DOI:10.1016/j.hpr.2025.300795