Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders

A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with d...

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Vydané v:Acta neuropathologica Ročník 119; číslo 6; s. 689 - 702
Hlavní autori: Beach, Thomas G., Adler, Charles H., Sue, Lucia I., Vedders, Linda, Lue, LihFen, White III, Charles L., Akiyama, Haru, Caviness, John N., Shill, Holly A., Sabbagh, Marwan N., Walker, Douglas G.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Berlin/Heidelberg Springer-Verlag 01.06.2010
Predmet:
Aged
Aged, 80 and over
alpha-Synuclein - metabolism
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Brain - metabolism
Brain - pathology
Female
Ganglia, Sympathetic - metabolism
Ganglia, Sympathetic - pathology
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - pathology
Humans
Immunohistochemistry
Lewy Body Disease - metabolism
Lewy Body Disease - pathology
Male
Medicine
Medicine & Public Health
Neurosciences
Original Paper
Parkinson Disease - metabolism
Parkinson Disease - pathology
Pathology
Peripheral Nervous System - metabolism
Peripheral Nervous System - pathology
Phosphorylation
Spinal Cord - metabolism
Spinal Cord - pathology
Peripheral nervous system
Heart
α-Synuclein
Stomach
Spinal cord
Alzheimer’s disease
Submandibular gland
Sympathetic nervous system
Esophagus
Parkinsonism
Enteric nervous system
Autonomic nervous system
Gastrointestinal system
Adrenal gland
Parkinson’s disease
Incidental Lewy bodies
Dementia with Lewy bodies
ISSN:0001-6322, 1432-0533, 1432-0533
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Shrnutí:A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, including 23 normal elderly, 7 with incidental Lewy body disease (ILBD), 17 with Parkinson’s disease (PD), 9 with dementia with Lewy bodies (DLB), 19 with Alzheimer’s disease with Lewy bodies (ADLB) and 17 with Alzheimer’s disease with no Lewy bodies (ADNLB). The relative densities and frequencies of occurrence of phosphorylated α-synuclein histopathology (PASH) were tabulated and correlated with diagnostic category. The greatest densities and frequencies of PASH occurred in the spinal cord, followed by the paraspinal sympathetic ganglia, the vagus nerve, the gastrointestinal tract and endocrine organs. The frequency of PASH within other organs and tissue types was much lower. Spinal cord and peripheral PASH was most common in subjects with PD and DLB, where it appears likely that it is universally widespread. Subjects with ILBD had lesser densities of PASH within all regions, but had frequent involvement of the spinal cord and paraspinal sympathetic ganglia, with less-frequent involvement of end-organs. Subjects with ADLB had infrequent involvement of the spinal cord and paraspinal sympathetic ganglia with rare involvement of end-organs. Within the gastrointestinal tract, there was a rostrocaudal gradient of decreasing PASH frequency and density, with the lower esophagus and submandibular gland having the greatest involvement and the colon and rectum the lowest.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0001-6322
1432-0533
1432-0533
DOI:10.1007/s00401-010-0664-3